Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | THPO | P40225 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Merophan SCHEMBL31473334 | 0.85 | CYP1A2 (0.48) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7513236 | 0.81 | TDP1 (0.40) | LMNAALOX15PMP22CHRM2ADRA2A | |
| SCHEMBL29462781 | 0.77 | SOAT1 (0.41) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL19732329 | 0.77 | ALDH1A1 (0.45) | ALDH1A1LMNAKMT2APTGS1NFKB1 | |
| SCHEMBL5252487 | 0.77 | TDP1 (0.39) | LMNAALOX15PMP22CHRM2ADRA2A | |
| SCHEMBL9435308 | 0.77 | TDP1 (0.39) | LMNAALOX15PMP22CHRM2ADRA2A | |
| SCHEMBL10336122 | 0.74 | HIF1A (0.48) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7271045 | 0.73 | PTGS1 (0.47) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27863169 | 0.73 | PTGS1 (0.47) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2565363 | 0.73 | LDHA (0.50) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170226047-A1 | PROCESS FOR THE PURIFICATION OF MELPHALAN | FARMABIOS SPA (IT) | 2017-08-10 | — | — | US | disclosed |
| US-9663450-B2 | Process for the purification of melphalan | FARMABIOS S.P.A. (IT) | 2017-05-30 | — | — | US | disclosed |
| US-20160090352-A1 | PROCESS FOR THE PURIFICATION OF MELPHALAN | FARMABIOS S.P.A (IT) | 2016-03-31 | — | — | US | disclosed |
| WO-2014191426-A1 | PROCESS FOR THE PURIFICATION OF MELPHALAN | FARMABIOS S.P.A. (IT) | 2014-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160090352-A1 | PROCESS FOR THE PURIFICATION OF MELPHALAN | MYADM, MANBA, PTMA | HIF1A 1379/4885CYP3A4 3173/4885ALDH1A1 3594/4885 |
| US-20170226047-A1 | PROCESS FOR THE PURIFICATION OF MELPHALAN | MYADM, MANBA, PTMA | HIF1A 1379/4885CYP3A4 3173/4885ALDH1A1 3594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.