SCHEMBL1629985

SCHEMBL1629985

Brc1cc(-c2cccs2)sc1-c1cccs1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.41
MAPT P10636 4/20 0.41
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
NPC1 O15118 2/20 0.41
HDAC1 Q13547 1/20 0.40
TDP1 Q9NUW8 2/20 0.39
RAB9A P51151 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
PPARG P37231 1/20 0.39
NCOA2 Q15596 1/20 0.39
NCOA1 Q15788 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
NCOA3 Q9Y6Q9 1/20 0.39
LTA4H P09960 1/20 0.39
DPP4 P27487 3/20 0.38
ALDH1A1 P00352 4/20 0.37
L3MBTL1 Q9Y468 3/20 0.37
LMNA P02545 2/20 0.37
GAA P10253 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14832748 0.85 NPC1 (0.38) KDM4EMAPTMEN1KMT2ANPC1
SCHEMBL4819905 0.84 MEN1 (0.41) KDM4EMAPTMEN1KMT2ANPC1
SCHEMBL14832687 0.82 HDAC1 (0.41) KDM4EMAPTMEN1KMT2ANPC1
SCHEMBL28878431 0.81 MEN1 (0.39) KDM4EMAPTMEN1KMT2ANPC1
SCHEMBL4463311 0.78 HDAC1 (0.39) KDM4EMAPTMEN1KMT2ANPC1
SCHEMBL916593 0.78 KDM4E (0.40) KDM4EMAPTNPC1HDAC1TDP1
SCHEMBL14838439 0.78 SNCA (0.41) KDM4EMAPTNPC1HDAC1SMN1; SMN2
SCHEMBL14838358 0.78 MAPT (0.49) KDM4EMAPTMEN1KMT2ANPC1
SCHEMBL20146989 0.78 KDM4E (0.33) KDM4EMAPTNPC1HDAC1TDP1
SCHEMBL14832847 0.78 SNCA (0.41) KDM4EMAPTHDAC1SMN1; SMN2LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3947596-A1 PHOTOCHROMIC AND ELECTROCHROMIC DIARYLETHENE COMPOUNDS WITH IMPROVED PHOTOSTABILITY AND SOLUBILITY Solutia Canada Inc. (CA) 2022-02-09 EP claimed
WO-2020198868-A1 PHOTOCHROMIC AND ELECTROCHROMIC DIARYLETHENE COMPOUNDS WITH IMPROVED PHOTOSTABILITY AND SOLUBILITY SWITCH MATERIALS INC. (CA) 2020-10-08 WO claimed
CN-119951355-A Water body heavy metal ion pollution treatment adsorption filtration membrane and preparation method thereof 武汉轻工大学 2025-05-09 CN disclosed
CN-119638727-A Terpyridyl zinc complex and preparation method and application thereof 中南大学 2025-03-18 CN disclosed
US-12202954-B2 Rubber composition and crosslinked rubber molded product SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2025-01-21 US disclosed
US-20230114853-A1 RUBBER COMPOSITION AND CROSSLINKED RUBBER MOLDED PRODUCT SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2023-04-13 US disclosed
US-20220220100-A1 PHOTOCHROMIC AND ELECTROCHROMIC DIARYLETHENE COMPOUNDS WITH IMPROVED PHOTOSTABILITY AND SOLUBILITY SWITCH MATERIALS INC. (CA) 2022-07-14 US disclosed
CN-108884114-B Electron-accepting compound, composition for charge transport film, and light-emitting element using same 三菱化学株式会社 2022-02-25 CN disclosed
CN-114040959-A Photochromic and electrochromic diarylethene compounds with improved photostability and solubility 首诺加拿大公司 2022-02-11 CN disclosed
EP-3947596-A1 PHOTOCHROMIC AND ELECTROCHROMIC DIARYLETHENE COMPOUNDS WITH IMPROVED PHOTOSTABILITY AND SOLUBILITY Solutia Canada Inc. (CA) 2022-02-09 EP disclosed
US-11124524-B2 Diarylethene compounds and uses thereof SOLUTIA CANADA INC. (US) 2021-09-21 US disclosed
US-20110003966-A1 PHOTOCHROMIC AND ELETROCHROMIC COMPOUNDS AND METHODS OF SYNTHESIZING AND USING SAME SWITCH MATERIALS INC. (CA) 2011-01-06 US disclosed
US-20110003966-A1 PHOTOCHROMIC AND ELETROCHROMIC COMPOUNDS AND METHODS OF SYNTHESIZING AND USING SAME SWITCH MATERIALS INC. (CA) 2011-01-06 US disclosed
US-7777055-B2 Photochromic and electrochromic compounds and methods of synthesizing and using same SWITCH MATERIALS INC. (CA) 2010-08-17 US disclosed
US-7777055-B2 Photochromic and electrochromic compounds and methods of synthesizing and using same SWITCH MATERIALS INC. (CA) 2010-08-17 US disclosed
US-7777055-B2 Photochromic and electrochromic compounds and methods of synthesizing and using same SWITCH MATERIALS INC. (CA) 2010-08-17 US disclosed
US-7161013-B2 Terthiophene-3-carboxylic acid compound and fabricating method thereof, functionalized conductive terthiophene polymer with the compound as a monomer, process for DNA hybridization detection using the polymer, and fabricating method of probe DNA PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) 2007-01-09 US disclosed
US-7161013-B2 Terthiophene-3-carboxylic acid compound and fabricating method thereof, functionalized conductive terthiophene polymer with the compound as a monomer, process for DNA hybridization detection using the polymer, and fabricating method of probe DNA PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) 2007-01-09 US disclosed
US-20060240197-A1 Photochromic and electrochromic compounds and methods of synthesizing and using same SOLUTIA CANADA INC. (CA) 2006-10-26 US disclosed
WO-2004015024-A1 PHOTOCHROMIC AND ELECTROCHROMIC COMPOUNDS AND METHODS OF SYNTHESIZING AND USING SAME SIMON FRASER UNIVERSITY (CA) 2004-02-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060240197-A1 Photochromic and electrochromic compounds and methods of synthesizing and using same TET1, HMBS, MECP2 KDM4E 2521/4885MAPT 62/4885MEN1 1812/4885
US-11124524-B2 Diarylethene compounds and uses thereof KCNH2, KCNH3, SCN2B KDM4E 1996/4885MAPT 4557/4885MEN1 4315/4885
US-20220220100-A1 PHOTOCHROMIC AND ELECTROCHROMIC DIARYLETHENE COMPOUNDS WITH IMPROVED PHOTOSTABILITY AND SOLUBILITY CYP1B1, POR, CYP4B1 KDM4E 1085/4885MAPT 2603/4885MEN1 3855/4885
US-20110003966-A1 PHOTOCHROMIC AND ELETROCHROMIC COMPOUNDS AND METHODS OF SYNTHESIZING AND USING SAME TET1, MECP2, EYA2 KDM4E 2641/4885MAPT 21/4885MEN1 1702/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.