Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680184 | 0.80 | PTGS2 (0.53) | SCN9ASCN3ABCL2L1MCL1MEN1 | |
| SCHEMBL679939 | 0.76 | MEN1 (0.60) | SCN9ASCN3ABCL2L1MCL1MEN1 | |
| SCHEMBL679956 | 0.76 | MAPK14 (0.55) | SCN9ASCN3ABCL2L1MCL1SCN5A | |
| SCHEMBL680159 | 0.74 | CXCL8 (0.59) | SCN9ASCN3ABCL2L1MCL1SCN5A | |
| SCHEMBL680618 | 0.74 | MAPK14 (0.54) | SCN9ASCN3AMAPK14MEN1KMT2A | |
| SCHEMBL680509 | 0.72 | SCN3A (0.50) | SCN9ASCN3ABCL2L1MCL1MEN1 | |
| SCHEMBL680203 | 0.72 | SCN3A (0.45) | SCN9ASCN3ABCL2L1MCL1MEN1 | |
| SCHEMBL680339 | 0.72 | KMT2A (0.51) | SCN9ASCN3ABCL2L1MCL1PIN1 | |
| SCHEMBL680151 | 0.72 | MAPK14 (0.61) | SCN9ASCN3ABCL2L1MCL1SCN5A | |
| SCHEMBL679137 | 0.72 | RORC (0.52) | SCN9ASCN3ABCL2L1MCL1SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |