Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.52 |
| ▸ | NPC1 | O15118 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16320026 | 0.88 | HCAR3 (0.48) | RAB9ANPC1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL16320397 | 0.84 | FAAH (0.44) | — | |
| SCHEMBL16319440 | 0.83 | SMN1; SMN2 (0.48) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL16319748 | 0.81 | FYN (0.43) | RAB9ANPC1SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL16319555 | 0.80 | HPGD (0.45) | RAB9ANPC1HPGDCYP1A2CYP2C19 | |
| SCHEMBL8170956 | 0.78 | F2 (0.40) | KDM4E | |
| SCHEMBL14911306 | 0.77 | NPC1 (0.65) | RAB9ANPC1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL16319842 | 0.76 | BMPR1B (0.45) | RAB9ANPC1HPGDL3MBTL1LMNA | |
| SCHEMBL6707186 | 0.75 | RAB9A (0.79) | RAB9ANPC1SMN1; SMN2HPGDTP53 | |
| SCHEMBL730329 | 0.75 | NPC1 (0.62) | RAB9ANPC1SMN1; SMN2HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544684-B1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-24 | — | — | EP | disclosed |