Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332414 | 0.91 | GABRG2 (0.54) | EGFRSRCFGFR1GABRG2GABRB3 | |
| SCHEMBL16332664 | 0.81 | GABRG2 (0.55) | FLT3EGFRGABRG2GABRB3GABRA5 | |
| SCHEMBL16332413 | 0.78 | RHOA (0.47) | EGFRGABRG2GABRB3GABRA5 | |
| SCHEMBL16332798 | 0.76 | GABRG2 (0.46) | FLT3EGFRSRCFGFR1GABRG2 | |
| SCHEMBL16331646 | 0.76 | GABRG2 (0.46) | EGFRSRCGABRG2GABRB3GABRA5 | |
| SCHEMBL16331388 | 0.75 | BRD4 (0.51) | FYNFLT3EGFRSRCFGFR1 | |
| SCHEMBL16332930 | 0.75 | GABRG2 (0.68) | GABRG2GABRB3GABRA5 | |
| SCHEMBL16332751 | 0.73 | IGF1R (0.44) | FYNEGFRSRCFGFR1GABRG2 | |
| SCHEMBL16332276 | 0.72 | GABRG2 (0.67) | GABRG2GABRB3GABRA5MAPK9 | |
| SCHEMBL16332447 | 0.72 | PIK3CA (0.58) | GABRG2GABRB3GABRA5MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |