Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 6/20 | 0.68 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.68 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.50 |
| ▸ | PRKDC | P78527 | 3/20 | 0.50 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332664 | 0.92 | GABRG2 (0.55) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16331626 | 0.84 | GABRG2 (0.52) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16332798 | 0.83 | GABRG2 (0.46) | GABRG2GABRB3GABRA5 | |
| SCHEMBL16332602 | 0.79 | GABRG2 (0.52) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16332413 | 0.77 | RHOA (0.47) | GABRG2GABRB3GABRA5 | |
| SCHEMBL16331495 | 0.76 | CYP1A2 (0.53) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16331614 | 0.76 | GABRG2 (0.49) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL16331646 | 0.75 | GABRG2 (0.46) | GABRG2GABRB3GABRA5BRAF | |
| SCHEMBL16332414 | 0.75 | GABRG2 (0.54) | GABRG2GABRB3GABRA5 | |
| SCHEMBL16331561 | 0.74 | BRAF (0.56) | GABRG2GABRB3GABRA5PIK3CAPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |