Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332454 | 0.94 | L3MBTL1 (0.44) | RHOAMAPTALDH1A1NPSR1USP2 | |
| SCHEMBL16332371 | 0.91 | RHOA (0.45) | RHOAMAPTALDH1A1SMN1; SMN2FYN | |
| SCHEMBL16332413 | 0.84 | RHOA (0.47) | RHOAABCB1ABCC1ABCG2 | |
| SCHEMBL16332306 | 0.83 | RHOA (0.54) | RHOAMAPTALDH1A1SMN1; SMN2ABCB1 | |
| SCHEMBL16331810 | 0.82 | RHOA (0.45) | RHOAMAPTALDH1A1SMN1; SMN2KDM1A | |
| SCHEMBL16331460 | 0.81 | MAPT (0.47) | MAPTALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL16331429 | 0.81 | ALDH1A1 (0.42) | RHOAMAPTALDH1A1NPSR1USP2 | |
| SCHEMBL16332496 | 0.81 | GABRG2 (0.47) | MAPTALDH1A1NPSR1USP2SMN1; SMN2 | |
| SCHEMBL16331650 | 0.81 | PIK3CA (0.44) | RHOAMAPTALDH1A1ABCG2MEN1 | |
| SCHEMBL16331495 | 0.79 | CYP1A2 (0.53) | MAPTNPSR1SMN1; SMN2KDM1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |