Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | NAPEPLD | Q6IQ20 | 3/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.32 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8701795 | 0.87 | LTB4R (0.43) | OPRK1SIGMAR1NAPEPLDCYP2D6 | |
| SCHEMBL16333376 | 0.84 | SIGMAR1 (0.57) | OPRK1SIGMAR1KMT2AMEN1SIRT2 | |
| SCHEMBL8704031 | 0.82 | MAPT (0.38) | OPRK1SIGMAR1KMT2AMEN1 | |
| SCHEMBL8702756 | 0.82 | OPRM1 (0.46) | OPRK1SIGMAR1 | |
| SCHEMBL16333452 | 0.81 | KCNH2 (0.47) | OPRK1SIGMAR1CYP2D6 | |
| SCHEMBL6249500 | 0.81 | OPRK1 (0.49) | OPRK1KMT2AMEN1NAPEPLDSLC16A3 | |
| SCHEMBL6250215 | 0.80 | OPRK1 (0.50) | OPRK1NAPEPLDCYP2D6 | |
| SCHEMBL6472157 | 0.79 | OPRK1 (0.54) | OPRK1CYP2D6 | |
| Hydrochloric Acid SCHEMBL6477279 | 0.79 | OPRM1 (0.40) | OPRK1CYP2D6 | |
| SCHEMBL6251298 | 0.79 | CYP2D6 (0.52) | OPRK1SIGMAR1NAPEPLDSLC16A3SLC16A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013812-A2 | KAPPA OPIOID AGONISTS AND USES THEREOF | Nektar Therapeutics (US) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014210436-A2 | KAPPA OPIOID AGONISTS AND USES THEREOF | NEKTAR THERAPEUTICS (US) | 2014-12-31 | — | — | WO | disclosed |