Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 17/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 16/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 16/20 | 0.39 |
| ▸ | CASP1 | P29466 | 14/20 | 0.39 |
| ▸ | CASP7 | P55210 | 14/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.39 |
| ▸ | HPGD | P15428 | 10/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.39 |
| ▸ | GLA | P06280 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 10/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL2874748 | 0.74 | HSD17B10 (0.41) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 | |
| Maleic Acid SCHEMBL8812791 | 0.73 | HSD17B10 (0.43) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 | |
| Fumaric Acid SCHEMBL8812798 | 0.73 | HSD17B10 (0.43) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 | |
| Fumaric Acid SCHEMBL8810291 | 0.72 | HSD17B10 (0.40) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 | |
| Maleic Acid SCHEMBL8810283 | 0.72 | HSD17B10 (0.40) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 | |
| Maleic Acid SCHEMBL2880482 | 0.70 | HSD17B10 (0.41) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL10880395 | 0.68 | KDM4E (0.68) | ALDH1A1HSD17B10HPGDCYP2C19CYP3A4 | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL10877794 | 0.68 | KDM4E (0.68) | ALDH1A1HSD17B10HPGDCYP2C19CYP3A4 | |
| SCHEMBL1846525 | 0.66 | ALDH1A1 (0.44) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 | |
| SCHEMBL1847690 | 0.65 | ALDH1A1 (0.46) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326330-B1 | COMPOSITIONS FOR TREATING OR DELAYING THE ONSET OF HAIR LOSS | UNIV CENTRAL FLORIDA RES FOUND (US) | 2015-01-07 | — | — | EP | disclosed |