Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR known ✓ | P42345 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.40 |
| ▸ | CASP1 | P29466 | 9/20 | 0.40 |
| ▸ | CASP7 | P55210 | 9/20 | 0.40 |
| ▸ | USP2 | O75604 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8812798 | 1.00 | HSD17B10 (0.43) | HSD17B10CYP3A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL8809371 | 0.90 | ALDH1A1 (0.44) | HSD17B10CYP3A4KDM4EALDH1A1CYP1A2 | |
| Maleic Acid SCHEMBL2874748 | 0.78 | HSD17B10 (0.41) | HSD17B10CYP3A4KDM4EALDH1A1CYP1A2 | |
| Maleic Acid SCHEMBL16341994 | 0.73 | ALDH1A1 (0.39) | HSD17B10CYP3A4KDM4EALDH1A1CYP1A2 | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL10880395 | 0.72 | KDM4E (0.68) | HSD17B10CYP3A4KDM4EALDH1A1HPGD | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL10877794 | 0.72 | KDM4E (0.68) | HSD17B10CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL8810512 | 0.71 | ALDH1A1 (0.51) | HSD17B10CYP3A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL8808001 | 0.71 | HTT (0.67) | HSD17B10KDM4EALDH1A1CASP1USP2 | |
| Hydrochloric Acid SCHEMBL8809861 | 0.70 | ALDH1A1 (0.50) | HSD17B10CYP3A4KDM4EALDH1A1CYP1A2 | |
| Maleic Acid SCHEMBL2880482 | 0.69 | HSD17B10 (0.41) | HSD17B10CYP3A4KDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257102-B1 | AGENTS FOR TREATING NEUROPHATHY | MITSUI PETROCHEMICAL IND (JP) | 1997-11-19 | — | — | EP | disclosed |
| EP-0799617-A2 | Therapeutic agent for neurological diseases | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-08 | — | — | EP | disclosed |
| US-4959368-A | PYRIMIDINE DERIVATIVES | MITSUI PETROCHEMICAL INDUSTRIES LTD. (JP) | 1990-09-25 | — | — | US | disclosed |
| EP-0257102-A1 | AGENTS FOR TREATING NEUROPHATHY | Mitsui Chemicals, Inc. (JP) | 1988-03-02 | — | — | EP | disclosed |