SCHEMBL16355189

SCHEMBL16355189

COc1ccc(-c2c(-c3ccccc3Cl)nc(-c3ccccc3Cl)n2C2(c3ccccc3Cl)N=C(c3ccccc3)C(c3ccccc3)=N2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
KDM4E B2RXH2 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
LMNA P02545 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
APP P05067 1/20 0.37
BACE1 P56817 1/20 0.37
MAPT P10636 3/20 0.35
NPC1 O15118 1/20 0.35
MAPK1 P28482 1/20 0.35
RAB9A P51151 1/20 0.35
ATM Q13315 1/20 0.35
PIK3CD O00329 2/20 0.35
GLA P06280 1/20 0.35
HPGD P15428 2/20 0.35
TEK Q02763 1/20 0.35
PDE2A O00408 1/20 0.34
PDE10A Q9Y233 1/20 0.34
MGAM O43451 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16355186 0.96 KDM4E (0.43) ALDH1A1KDM4ENPSR1LMNATDP1
SCHEMBL16355187 0.96 KDM4E (0.43) ALDH1A1KDM4ENPSR1LMNATDP1
SCHEMBL3101056 0.94 KDM4E (0.39) ALDH1A1KDM4ENPSR1LMNATDP1
SCHEMBL30358508 0.94 KDM4E (0.39) ALDH1A1KDM4ENPSR1LMNATDP1
SCHEMBL16355184 0.91 PIK3CD (0.36) KDM4EL3MBTL1MAPTPIK3CDPDE2A
SCHEMBL16355190 0.89 BACE1 (0.39) ALDH1A1KDM4ENPSR1LMNATDP1
SCHEMBL31734215 0.89 L3MBTL1 (0.43) ALDH1A1KDM4ETDP1L3MBTL1MAPT
SCHEMBL16355181 0.89 L3MBTL1 (0.43) ALDH1A1KDM4ETDP1L3MBTL1MAPT
SCHEMBL16746549 0.87 APP (0.35) ALDH1A1KDM4ENPSR1LMNATDP1
SCHEMBL16355191 0.87 ALDH1A1 (0.41) ALDH1A1KDM4ELMNAL3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140374677-A1 COLORED COMPOSITION, COLORED PHOTOSENSITIVE COMPOSITION, COLOR FILTER AND LIQUID CRYSTAL DISPLAY DEVICE EQUIPPED WITH SAME, ORGANIC EL DISPLAY DEVICE, AND SOLID-STATE IMAGE SENSOR FUJIFILM CORPORATION (JP) 2014-12-25 US disclosed
US-20140374677-A1 COLORED COMPOSITION, COLORED PHOTOSENSITIVE COMPOSITION, COLOR FILTER AND LIQUID CRYSTAL DISPLAY DEVICE EQUIPPED WITH SAME, ORGANIC EL DISPLAY DEVICE, AND SOLID-STATE IMAGE SENSOR FUJIFILM CORPORATION (JP) 2014-12-25 US disclosed