Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15876021 | 1.00 | MAPT (0.47) | MAPTEPHX2NR1H4CYP17A1NAMPT | |
| SCHEMBL20143603 | 1.00 | MAPT (0.47) | MAPTEPHX2NR1H4CYP17A1NAMPT | |
| SCHEMBL30182358 | 0.90 | NAMPT (0.51) | MAPTCYP17A1NAMPTRAB9ASMN1; SMN2 | |
| SCHEMBL16355697 | 0.90 | MEN1 (0.47) | MAPTCYP17A1PTPN11ALDH1A1KMT2A | |
| SCHEMBL14155353 | 0.89 | CYP17A1 (0.48) | NR1H4CYP17A1NAMPTPTPN11MAPKAPK2 | |
| SCHEMBL10092627 | 0.89 | CYP17A1 (0.48) | NR1H4CYP17A1NAMPTPTPN11MAPKAPK2 | |
| SCHEMBL30725576 | 0.88 | SMN1; SMN2 (0.43) | MAPTCYP17A1NAMPTMAPKAPK2PSMB8 | |
| SCHEMBL3785111 | 0.88 | CTSK (0.41) | NR1H4CYP17A1NAMPTPTPN11CA12 | |
| SCHEMBL13785635 | 0.88 | CTSK (0.41) | NR1H4CYP17A1NAMPTPTPN11CA12 | |
| SCHEMBL3785113 | 0.88 | CTSK (0.41) | NR1H4CYP17A1NAMPTPTPN11CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11465965-B2 | Double-headed protease inhibitor | UBE INDUSTRIES, LTD. (JP) | 2022-10-11 | — | — | US | disclosed |
| US-20220281866-A1 | 5,8-DISUBSTITUTED-[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL AND 5,8-DISUBSTITUTED-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF ENTEROPEPTIDASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-08 | — | — | US | disclosed |
| US-20210403420-A1 | BENZOATE COMPOUND | SCOHIA PHARMA, INC. (JP) | 2021-12-30 | — | — | US | disclosed |
| WO-2021013742-A1 | 5,8-DISUBSTITUTED-[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL AND 5,8-DISUBSTITUTED-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF ENTEROPEPTIDASE | JANSSEN PHARMACEUTICA NV (BE) | 2021-01-28 | — | — | WO | disclosed |
| US-20200347011-A1 | DOUBLE-HEADED PROTEASE INHIBITOR | UBE INDUSTRIES, LTD. (JP) | 2020-11-05 | — | — | US | disclosed |
| EP-3705471-A1 | DOUBLE-HEADED PROTEASE INHIBITOR | UBE Industries, Ltd. (JP) | 2020-09-09 | — | — | EP | disclosed |
| EP-3705471-A1 | DOUBLE-HEADED PROTEASE INHIBITOR | UBE Industries, Ltd. (JP) | 2020-09-09 | — | — | EP | disclosed |
| EP-3650440-A1 | BENZOIC ESTER COMPOUND | Scohia Pharma, Inc. (JP) | 2020-05-13 | — | — | EP | disclosed |
| US-9969709-B2 | Guanidinobenzoic acid ester compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-15 | — | — | US | disclosed |
| US-20160031847-A1 | GUANIDINOBENZOIC ACID ESTER COMPOUND | ASTELLAS PHARMA INC. (JP) | 2016-02-04 | — | — | US | disclosed |
| US-9199927-B2 | Guanidinobenzoic acid compound | ASTELLAS PHARMA INC. (JP) | 2015-12-01 | — | — | US | disclosed |
| US-20140378459-A1 | GUANIDINOBENZOIC ACID COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200347011-A1 | DOUBLE-HEADED PROTEASE INHIBITOR | TMPRSS15, SPINT2, PRSS2 | MAPT 2861/4885EPHX2 439/4885NR1H4 1119/4885 |
| US-20160031847-A1 | GUANIDINOBENZOIC ACID ESTER COMPOUND | SERPINB1, REN, SPINT2 | MAPT 2721/4885EPHX2 1108/4885NR1H4 241/4885 |
| US-20220281866-A1 | 5,8-DISUBSTITUTED-[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL AND 5,8-DISUBSTITUTED-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF ENTEROPEPTIDASE | TMPRSS15, DPP8, SI | MAPT 2544/4885EPHX2 519/4885NR1H4 231/4885 |
| US-20210403420-A1 | BENZOATE COMPOUND | TMPRSS15, DPP4, DPP3 | MAPT 3791/4885EPHX2 741/4885NR1H4 341/4885 |
| US-11465965-B2 | Double-headed protease inhibitor | TMPRSS15, SPINT2, PRSS2 | MAPT 2861/4885EPHX2 439/4885NR1H4 1119/4885 |
| US-20140378459-A1 | GUANIDINOBENZOIC ACID COMPOUND | SERPINB1, REN, SPINT2 | MAPT 1339/4885EPHX2 1224/4885NR1H4 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.