Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.41 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 18/20 | 0.41 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834534 | 0.80 | P2RX3 (0.42) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL21499674 | 0.79 | TRPC4 (0.41) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19375602 | 0.78 | ADORA3 (0.43) | TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL21316302 | 0.77 | TRPC4 (0.41) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL16029108 | 0.74 | TRPC5 (0.74) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL18834247 | 0.74 | P2RX3 (0.35) | P2RX3 | |
| SCHEMBL19374868 | 0.73 | P2RX3 (0.36) | P2RX3 | |
| SCHEMBL16028626 | 0.73 | TRPC5 (0.62) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19375494 | 0.72 | TRPC4 (0.43) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL20432257 | 0.71 | TRPC5 (0.50) | TRPC4TRPC5KCNH2P2RX3TRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |
| WO-2014143799-A9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, INC. (US) | 2014-12-24 | — | — | WO | disclosed |