SCHEMBL5583675

SCHEMBL5583675

COc1ccnc(C(=O)Nc2ccc(C(C)(C)C)cc2Cl)c1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
LMNA P02545 3/20 0.48
MAPT P10636 3/20 0.48
RAB9A P51151 2/20 0.48
HPGD P15428 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
KDM4E B2RXH2 1/20 0.48
NPY1R P25929 1/20 0.48
NPY2R P49146 1/20 0.48
HTT P42858 2/20 0.44
TSHR P16473 1/20 0.44
CYP2C19 P33261 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
POLB P06746 2/20 0.41
TDP1 Q9NUW8 1/20 0.41
NR1I2 O75469 6/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5583578 0.81 SMN1; SMN2 (0.53) LMNAMAPTRAB9ASMN1; SMN2NR1I2
SCHEMBL5584058 0.80 NR1I2 (0.50) ALDH1A1MAPTSMN1; SMN2KDM4ETSHR
SCHEMBL5583560 0.79 PKM (0.42) MAPTRAB9AHPGDSMN1; SMN2HTT
SCHEMBL5583850 0.76 KDR (0.50) LMNAMAPTRAB9ASMN1; SMN2HTT
SCHEMBL5583592 0.75 GRM4 (0.54) ALDH1A1LMNAMAPTRAB9AHPGD
SCHEMBL5583759 0.75 KDR (0.47) LMNAMAPTRAB9ASMN1; SMN2MEN1
SCHEMBL5583713 0.74 KDR (0.46) MAPTSMN1; SMN2NR1I2
SCHEMBL5583664 0.74 KDR (0.45) ALDH1A1HPGDCYP2C19CYP1A2CYP3A4
SCHEMBL5583672 0.73 SCN9A (0.54) ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E
SCHEMBL5583752 0.73 MAPT (0.57) MAPTRAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US disclosed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP disclosed