SCHEMBL16389671

SCHEMBL16389671

Cn1c(-c2ncc(C(F)(F)F)cc2S(C)(=O)=O)nc2cc(C(F)(F)F)ncc21

nearest known ligand 0.35

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 16/20 0.35
▸ PTGS1 P23219 6/20 0.35
▸ PDE2A O00408 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18624698 0.90 PDE2A (0.35) PTGS2PTGS1PDE2A
SCHEMBL17018436 0.89 POLB (0.35) —
SCHEMBL21925089 0.88 S1PR1 (0.32) PTGS2PTGS1
SCHEMBL21925095 0.86 POLB (0.33) —
SCHEMBL17008988 0.81 RAB9A (0.43) PDE2A
SCHEMBL19366944 0.81 KCNH2 (0.35) PTGS2PTGS1
SCHEMBL24313900 0.81 S1PR1 (0.34) —
SCHEMBL29904267 0.81 S1PR1 (0.34) —
SCHEMBL24313905 0.80 S1PR1 (0.34) —
SCHEMBL24314118 0.80 S1PR1 (0.34) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115599-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2025-04-10 — — US disclosed
US-20230087882-A1 2-(Het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides BAYER CROPSCIENCE AG (DE) 2023-03-23 — — US disclosed
US-20220104496-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2022-04-07 — — US disclosed
US-11274097-B2 2-(het)aryl-substituted condensed bicyclic heterocycle derivatives as pest control agents BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2022-03-15 — — US disclosed
US-11274097-B2 2-(het)aryl-substituted condensed bicyclic heterocycle derivatives as pest control agents BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2022-03-15 — — US disclosed
US-11229208-B2 Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents SYNGENTA PARTICIPATIONS AG (CH) 2022-01-25 — — US disclosed
US-11229208-B2 Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents SYNGENTA PARTICIPATIONS AG (CH) 2022-01-25 — — US disclosed
US-10939682-B2 Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents SYNGENTA PARTICIPATIONS AG (CH) 2021-03-09 — — US disclosed
US-10939682-B2 Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents SYNGENTA PARTICIPATIONS AG (CH) 2021-03-09 — — US disclosed
EP-3778598-A2 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2021-02-17 — — EP disclosed
US-10364243-B2 2-(het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-07-30 — — US disclosed
US-20170073342-A1 2-(HET)ARYL-SUBSTITUTED FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-03-16 — — US disclosed
US-20170073342-A1 2-(HET)ARYL-SUBSTITUTED FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-03-16 — — US disclosed
EP-3107912-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS Bayer CropScience Aktiengesellschaft (DE) 2016-12-28 — — EP disclosed
US-20160255837-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2016-09-08 — — US disclosed
US-20160255837-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2016-09-08 — — US disclosed
US-20160255837-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2016-09-08 — — US disclosed
WO-2015121136-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS BAYER CROPSCIENCE AG (DE) 2015-08-20 — — WO disclosed
WO-2015121136-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS BAYER CROPSCIENCE AG (DE) 2015-08-20 — — WO disclosed
WO-2015000715-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2015-01-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11274097-B2 2-(het)aryl-substituted condensed bicyclic heterocycle derivatives as pest control agents CYP8B1, CYP4B1, CYP1B1 PTGS2 97/4885PTGS1 204/4885PDE2A 1309/4885
US-20220104496-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS GSTA1, CYP1B1, DDT PTGS2 763/4885PTGS1 241/4885PDE2A 1770/4885
US-20160255837-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS DDT, TST, SCLY PTGS2 992/4885PTGS1 1489/4885PDE2A 3661/4885
US-10939682-B2 Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents DDT, TST, SCLY PTGS2 992/4885PTGS1 1489/4885PDE2A 3661/4885
US-10364243-B2 2-(het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides CYP1B1, CYP4B1, CYP8B1 PTGS2 233/4885PTGS1 415/4885PDE2A 1291/4885
US-11229208-B2 Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents GSTA1, CYP1B1, DDT PTGS2 763/4885PTGS1 241/4885PDE2A 1770/4885
US-20230087882-A1 2-(Het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides CYP1B1, CYP4B1, CYP8B1 PTGS2 235/4885PTGS1 429/4885PDE2A 1231/4885
US-20170073342-A1 2-(HET)ARYL-SUBSTITUTED FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES CYP1B1, CYP4B1, CYP8B1 PTGS2 233/4885PTGS1 415/4885PDE2A 1291/4885
US-20250115599-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS CYP8B1, CYP4B1, CYP1B1 PTGS2 97/4885PTGS1 204/4885PDE2A 1309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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