SCHEMBL16403246

SCHEMBL16403246

Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C#N

nearest known ligand 0.72

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GUCY1B2 O75343 14/20 0.58
GUCY1A2 P33402 14/20 0.58
GUCY1A1 Q02108 14/20 0.58
GUCY1B1 Q02153 14/20 0.58
CYP1A2 P05177 1/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2D6 P10635 1/20 0.57
CYP2C9 P11712 1/20 0.57
CYP2C19 P33261 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17028964 0.91 GUCY1B2 (0.52) GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP1A2
SCHEMBL16402699 0.89 GUCY1B2 (0.57) GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP1A2
SCHEMBL16402969 0.86 GUCY1B2 (0.54) GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP1A2
SCHEMBL18801023 0.86 CYP1A2 (0.76) GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP1A2
SCHEMBL19414228 0.85 GUCY1B2 (0.53) GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP1A2
SCHEMBL19414229 0.85 GUCY1B2 (0.58) GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP1A2
SCHEMBL16402956 0.85 GUCY1B2 (0.46) GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP1A2
SCHEMBL8565905 0.84 GUCY1B2 (0.59) GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP1A2
SCHEMBL20528798 0.84 ATP4A (0.67) GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP1A2
SCHEMBL16399537 0.84 GUCY1B2 (0.59) GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3227287-B1 HETEROARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE Bayer Pharma AG (DE) 2019-08-07 EP disclosed
EP-3227287-B1 HETEROARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE Bayer Pharma AG (DE) 2019-08-07 EP disclosed
US-10292970-B2 Heteroaryl-substituted imidazo[1,2-A]pyridines and their use BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-05-21 US disclosed
US-10292970-B2 Heteroaryl-substituted imidazo[1,2-A]pyridines and their use BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-05-21 US disclosed
US-20170304278-A1 HETEROARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-10-26 US disclosed
US-20170304278-A1 HETEROARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-10-26 US disclosed
US-20170304278-A1 HETEROARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-10-26 US disclosed
EP-3107920-B1 3-(PYRIMIDINE-2-YL)IMIDAZO[1,2-A]PYRIDINES Bayer Pharma AG (DE) 2017-10-18 EP disclosed
EP-3107920-B1 3-(PYRIMIDINE-2-YL)IMIDAZO[1,2-A]PYRIDINES Bayer Pharma AG (DE) 2017-10-18 EP disclosed
EP-3227287-A1 HETEROARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE Bayer Pharma Aktiengesellschaft (DE) 2017-10-11 EP disclosed
US-20160347770-A1 3-(PYRIMIDINE-2-YL)IMIDAZO[1,2-A]PYRIDINES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-12-01 US disclosed
WO-2016087343-A1 HETEROARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-06-09 WO disclosed
WO-2016087343-A1 HETEROARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-06-09 WO disclosed
US-20160122341-A1 3-ARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-05-05 US disclosed
US-20160122341-A1 3-ARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-05-05 US disclosed
US-20160122341-A1 3-ARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-05-05 US disclosed
EP-3004094-A1 3-ARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THE USE THEREOF Bayer Pharma Aktiengesellschaft (DE) 2016-04-13 EP disclosed
WO-2015124544-A1 3-(PYRIMIDINE-2-YL)IMIDAZO[1,2-A]PYRIDINES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-08-27 WO disclosed
WO-2015124544-A1 3-(PYRIMIDINE-2-YL)IMIDAZO[1,2-A]PYRIDINES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-08-27 WO disclosed
WO-2014195333-A1 3-ARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THE USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2014-12-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160122341-A1 3-ARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE PNPO, PAH, TNNI3 GUCY1B2 1428/4885GUCY1A2 716/4885GUCY1A1 1083/4885
US-20170304278-A1 HETEROARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND THEIR USE TNNI3, CYP11B2, PPIP5K2 GUCY1B2 1819/4885GUCY1A2 876/4885GUCY1A1 1463/4885
US-20160347770-A1 3-(PYRIMIDINE-2-YL)IMIDAZO[1,2-A]PYRIDINES TPMT, PNPO, PDXK GUCY1B2 1123/4885GUCY1A2 676/4885GUCY1A1 1328/4885
US-10292970-B2 Heteroaryl-substituted imidazo[1,2-A]pyridines and their use TNNI3, CYP11B2, PPIP5K2 GUCY1B2 1819/4885GUCY1A2 876/4885GUCY1A1 1463/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.