Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 3/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20072258 | 0.91 | CES2 (0.38) | CES2ARPDE2ACACNA1HCACNA1C | |
| SCHEMBL24032646 | 0.88 | POLB (0.38) | ARPDE2AKIF11 | |
| SCHEMBL23791246 | 0.87 | RAPGEF4 (0.39) | RAPGEF4CES2LDHALDHBPDE2A | |
| SCHEMBL21139491 | 0.82 | PDE2A (0.44) | PDE2A | |
| SCHEMBL12534593 | 0.82 | HTR2A (0.33) | CACNA1CHTR2AHTR2CHTR2B | |
| SCHEMBL21139479 | 0.82 | PDE2A (0.41) | CES2ARPDE2ACACNA1HCACNA1C | |
| SCHEMBL13799252 | 0.82 | PDE2A (0.33) | CES2ARPDE2ACACNA1HCACNA1C | |
| SCHEMBL19871661 | 0.80 | RAPGEF4 (0.33) | RAPGEF4 | |
| SCHEMBL24105908 | 0.78 | SMN1; SMN2 (0.36) | RAPGEF4ARKIF11HTR2AHTR2C | |
| SCHEMBL27295732 | 0.78 | IL1B (0.37) | RAPGEF4LDHALDHBPDE2ACACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220141-A1 | INHIBITORS OF GLUTATHIONE S-TRANSFERASE ZETA 1 (GSTZ1) AND METHODS OF USE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| US-20230137110-A1 | ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE THEREOF | Beijing Summer Sprout Technology Co., Ltd. (CN) | 2023-05-04 | — | — | US | disclosed |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2018-04-19 | — | — | US | disclosed |
| US-9795953-B2 | Organometallic catalysts | BERGEN TEKNOLOGIOVERFORING AS (NO) | 2017-10-24 | — | — | US | disclosed |
| US-20160214098-A1 | NOVEL ORGANOMETALLIC CATALYSTS | BERGEN TEKNOLOGIOVERFORING AS (NO) | 2016-07-28 | — | — | US | disclosed |
| US-9303100-B2 | Organometallic catalysts | BERGEN TEKNOLOGIOVERFORING AS (NO) | 2016-04-05 | — | — | US | disclosed |
| US-20150025212-A1 | NOVEL ORGANOMETALLIC CATALYSTS | BERGEN TEKNOLOGIOVERFORING AS (NO) | 2015-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230137110-A1 | ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE THEREOF | SLCO2B1, SLCO2A1, SLCO1B3 | RAPGEF4 4038/4885CES2 1235/4885LDHA 59/4885 |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | PHGDH, PGD, PGK1 | RAPGEF4 2965/4885CES2 3921/4885LDHA 272/4885 |
| US-20160214098-A1 | NOVEL ORGANOMETALLIC CATALYSTS | ZKSCAN2, ZC3HAV1L, ZRANB2 | RAPGEF4 1279/4885CES2 3600/4885LDHA 2147/4885 |
| US-20150025212-A1 | NOVEL ORGANOMETALLIC CATALYSTS | ZKSCAN2, ZC3HAV1L, ZRANB2 | RAPGEF4 1279/4885CES2 3600/4885LDHA 2147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.