Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17757390 | 0.89 | HDAC3 (0.34) | MAPTSLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL16410627 | 0.88 | SLC6A2 (0.33) | MAPTSLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL16410778 | 0.85 | LMNA (0.38) | MAPTKDM4ELMNAGAA | |
| SCHEMBL16410834 | 0.80 | ACAT2 (0.36) | MAPTKDM4E | |
| SCHEMBL16410809 | 0.78 | ACAT2 (0.35) | — | |
| SCHEMBL16410799 | 0.78 | LMNA (0.32) | KDM4ELMNAALDH1A1 | |
| SCHEMBL17757469 | 0.78 | HDAC3 (0.35) | MAPTSLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL17757296 | 0.78 | SLC6A2 (0.39) | MAPTSLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL17757225 | 0.77 | HDAC3 (0.34) | MAPTSLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL16410721 | 0.77 | SIGMAR1 (0.33) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |