Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | Q9HBH1 | 1/20 | 0.45 | |
| ▸ | SSTR3 | P32745 | 1/20 | 0.44 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21726052 | 0.89 | CA1 (0.51) | KLKB1LTA4HPDFSSTR3PLG | |
| SCHEMBL24774255 | 0.87 | LTA4H (0.49) | KLKB1LTA4HPDFSSTR3PLG | |
| SCHEMBL24774073 | 0.83 | KLKB1 (0.44) | KLKB1LTA4HPDFSSTR3CALCRL | |
| SCHEMBL15810600 | 0.82 | KLKB1 (0.43) | KLKB1LTA4HPDFSSTR3PLG | |
| SCHEMBL16645118 | 0.81 | FURIN (0.47) | KLKB1LTA4HPDFSSTR3CALCRL | |
| SCHEMBL13411054 | 0.80 | SSTR3 (0.60) | LTA4HSSTR3CALCRLMMP3HDAC8 | |
| SCHEMBL17067271 | 0.79 | KLKB1 (0.47) | KLKB1LTA4HPDFSSTR3CALCRL | |
| SCHEMBL16479322 | 0.78 | SSTR3 (0.53) | LTA4HSSTR3CALCRLSIRT2SIRT1 | |
| SCHEMBL23425577 | 0.76 | KLKB1 (0.45) | KLKB1LTA4HPDFSSTR3CALCRL | |
| SCHEMBL16946450 | 0.76 | FURIN (0.42) | KLKB1LTA4HPDFSSTR3CALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015012904-A2 | ANTIBODY-SN-38 IMMUNOCONJUGATES WITH A CL2A LINKER | IMMUNOMEDICS, INC. (US) | 2015-01-29 | — | — | WO | disclosed |