Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | Q9HBH1 | 1/20 | 0.41 | |
| ▸ | SSTR3 | P32745 | 1/20 | 0.41 |
| ▸ | FURIN | P09958 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29335395 | 0.87 | KLKB1 (0.43) | KLKB1LTA4HPDFSSTR3FURIN | |
| SCHEMBL21897675 | 0.87 | NPY4R (0.41) | FURINSIRT1SIRT2NPC1RAB9A | |
| SCHEMBL16645118 | 0.85 | FURIN (0.47) | KLKB1LTA4HPDFSSTR3FURIN | |
| SCHEMBL24864484 | 0.84 | KLKB1 (0.47) | KLKB1LTA4HPDFSSTR3MMP3 | |
| SCHEMBL21726052 | 0.83 | CA1 (0.51) | KLKB1LTA4HPDFSSTR3MMP3 | |
| SCHEMBL16418621 | 0.82 | KLKB1 (0.49) | KLKB1LTA4HPDFSSTR3MMP3 | |
| SCHEMBL16771793 | 0.81 | LTA4H (0.38) | LTA4HFURINSPHK1SIRT1SIRT2 | |
| SCHEMBL16946450 | 0.80 | FURIN (0.42) | KLKB1LTA4HPDFSSTR3FURIN | |
| SCHEMBL24774255 | 0.80 | LTA4H (0.49) | KLKB1LTA4HPDFSSTR3MMP3 | |
| SCHEMBL16479322 | 0.80 | SSTR3 (0.53) | LTA4HSSTR3MMP3SIRT1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150209445-A1 | BIFUNCTIONAL CYTOTOXIC AGENTS | PFIZER INC. | 2015-07-30 | — | — | US | disclosed |
| WO-2014093394-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. (US) | 2014-06-19 | — | — | WO | disclosed |
| WO-2014093640-A1 | HYDROXY-POLMER-DRUG-PROTEIN CONJUGATES | MERSANA THERAPEUTICS,INC. (US) | 2014-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150209445-A1 | BIFUNCTIONAL CYTOTOXIC AGENTS | PAICS, CYTH3, CYTH2 | KLKB1 1725/4885LTA4H 4273/4885PDF 2550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.