Sugi Predict

Sugi Predict / Compounds / SCHEMBL164399

SCHEMBL164399

SCHEMBL164399

Oc1cc2c(c3ccccc13)-c1ccccc1C2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 2/20 0.41
▸ CYP1A2 P05177 2/20 0.40
▸ CYP3A4 P08684 2/20 0.40
▸ TRPM4 Q8TD43 1/20 0.39
▸ NPC1 O15118 2/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ LMNA P02545 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ MAPT P10636 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ SRD5A2 P31213 1/20 0.39
▸ CA1 P00915 3/20 0.38
▸ CA2 P00918 3/20 0.38
▸ CA4 P22748 3/20 0.38
▸ CA6 P23280 3/20 0.38
▸ HTR2B P41595 2/20 0.38
▸ ADRA2A P08913 1/20 0.38
▸ SLC6A2 P23975 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30663206 1.00 MAOA (0.41) MAOACYP1A2CYP3A4TRPM4NPC1
SCHEMBL7742221 0.86 MAOA (0.53) MAOACYP1A2CYP3A4ALDH1A1MAPT
SCHEMBL10299768 0.85 CES1 (0.41) TRPM4NPC1RAB9ALMNASRD5A2
SCHEMBL24604946 0.81 BCHE (0.42) MAOATRPM4LMNAALDH1A1MAPT
SCHEMBL28358713 0.80 SLC6A2 (0.43) CYP3A4LMNAALDH1A1KDM4EADRA2A
SCHEMBL18780585 0.78 SRD5A2 (0.55) CYP1A2ALDH1A1MAPTKDM4EHPGD
SCHEMBL1009092 0.78 TRPA1 (0.39) MAOAALDH1A1MAPTKDM4ECA1
SCHEMBL1011006 0.78 SRD5A2 (0.59) CYP1A2NPC1RAB9AALDH1A1MAPT
SCHEMBL347717 0.78 MAOA (0.41) MAOACYP1A2CYP3A4NPC1RAB9A
Fluorene SCHEMBL28192829 0.76 TRPM4 (0.68) MAOACYP1A2CYP3A4TRPM4NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1966180-B1 PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2015-02-18 — — EP claimed
EP-1966180-A1 PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2008-09-10 — — EP claimed
WO-2007078529-A1 PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2007-07-12 — — WO claimed
US-20070138448-A1 Photochromic indeno-fused naphthopyrans TRANSITIONS OPTICAL LIMITED (IE) 2007-06-21 — — US claimed
EP-4713397-A1 INDENONAPHTHOPYRANS HAVING PERFLUOROALKYL SUBSTITUTED ARYL / HETEROARYL SULFIDE AT POSITION-11 Transitions Optical, Ltd. (IE) 2026-03-25 — — EP disclosed
WO-2024235463-A1 INDENONAPHTHOPYRANS HAVING PERFLUOROALKYL SUBSTITUTED ARYL / HETEROARYL SULFIDE AT POSITION-11 TRANSITIONS OPTICAL, LTD. (IE) 2024-11-21 — — WO disclosed
CN-112313210-B Photochromic indeno-fused naphthopyran compounds with reduced temperature dependence 光学转变有限公司 2024-03-15 — — CN disclosed
US-11874434-B2 Ophthalmic devices comprising photochromic materials with reactive substituents JOHNSON & JOHNSON VISION CARE, INC. (US) 2024-01-16 — — US disclosed
WO-2022148752-A9 PHOTOCHROMIC DYES AND POLYMERIC MATRIX FOR AN EFFICIENT DIMMING FILM Sony Group Corporation (JP) 2023-08-03 — — WO disclosed
US-11518751-B2 Photochromic indeno-fused naphthopyran compounds with reduced temperature dependence TRANSITIONS OPTICAL, LTD. (IE) 2022-12-06 — — US disclosed
US-20220137262-A1 OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS JOHNSON & JOHNSON VISION CARE (US) 2022-05-05 — — US disclosed
US-11256002-B2 Ophthalmic devices comprising photochromic materials with reactive substituents JOHNSON & JOHNSON VISION CARE, INC. (US) 2022-02-22 — — US disclosed
EP-1655293-A2 Chromene compound Tokuyama Corporation (JP) 2006-05-10 — — EP disclosed
US-6723859-B2 BASE STRUCTURE IS A CHROMENE(3,2-A)FLUORENE RING CONTAINING SPIRO-FUSED RINGS; PHOTOCHROMIC LENSES; LARGE FADING RATE, LESS COLOR WHEN DETERIORATED, AND EXCELLENT LIGHT RESISTANCE IN THE PHOTOCHROMIC PROPERTIES TOKUYAMA CORPORATION (JP) 2004-04-20 — — US disclosed
US-20040014995-A1 Chromene compounds KAWABATA YUICHIRO (JP) 2004-01-22 — — US disclosed
US-20030096117-A1 Chromene compound TOKUYAMA CORPORATION (JP) 2003-05-22 — — US disclosed
EP-1054010-B1 Chromene compound TOKUYAMA CORP (JP) 2002-07-24 — — EP disclosed
EP-1184379-A1 CHROMENE COMPOUND TOKUYAMA CORPORATION (JP) 2002-03-06 — — EP disclosed
US-6340765-B1 PHOTOCHROMIC DYES AND DEVELOPMENT TOKUYAMA CORPORATION (JP) 2002-01-22 — — US disclosed
EP-1054010-A1 Chromene compound TOKUYAMA CORPORATION (JP) 2000-11-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040014995-A1 Chromene compounds SMARCE1, SMARCB1, SMARCA2 MAOA 379/4885CYP1A2 630/4885CYP3A4 894/4885
US-20070138448-A1 Photochromic indeno-fused naphthopyrans INTS6, IPO4, NQO1 MAOA 1056/4885CYP1A2 822/4885CYP3A4 581/4885
US-11518751-B2 Photochromic indeno-fused naphthopyran compounds with reduced temperature dependence NR2E3, NR0B2, NR2C2 MAOA 3633/4885CYP1A2 59/4885CYP3A4 540/4885
US-20030096117-A1 Chromene compound SMARCE1, SMARCD2, SMARCB1 MAOA 398/4885CYP1A2 657/4885CYP3A4 922/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.