Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LGMN | Q99538 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16305337 | 0.84 | LGMN (0.47) | ALDH1A1KMT2ASMN1; SMN2TSHRKDM4E | |
| SCHEMBL25515887 | 0.84 | HTR3E (0.46) | ALDH1A1KMT2ASMN1; SMN2TSHRKDM4E | |
| SCHEMBL16437256 | 0.82 | ALDH1A1 (0.40) | ALDH1A1KMT2ASMN1; SMN2TSHRKDM4E | |
| SCHEMBL14804169 | 0.81 | LGMN (0.45) | ALDH1A1KMT2ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL16440143 | 0.81 | SLC6A2 (0.39) | ALDH1A1KMT2ASMN1; SMN2GAAALDH1A3 | |
| SCHEMBL12385978 | 0.80 | POLB (0.48) | ALDH1A1SMN1; SMN2MAPTHPGDPOLB | |
| SCHEMBL16440158 | 0.79 | LMNA (0.42) | ALDH1A1KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL24880834 | 0.79 | ALDH1A1 (0.46) | ALDH1A1KMT2ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL16305345 | 0.79 | ALDH1A1 (0.54) | ALDH1A1KMT2ASMN1; SMN2MAPTHPGD | |
| SCHEMBL24123772 | 0.78 | MCOLN3 (0.43) | ALDH1A1KMT2ASMN1; SMN2TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027601-B1 | SYK INHIBITORS | GILEAD SCIENCES INC (US) | 2017-10-25 | — | — | EP | disclosed |
| US-20160368918-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2016-12-22 | — | — | US | disclosed |
| US-9376441-B2 | Substituted pyrrolidines as SYK inhibitors | GILEAD SCIENCES, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-20150038488-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2015-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038488-A1 | SYK INHIBITORS | SYK, BTK, LYN | ALDH1A1 4200/4885KMT2A 850/4885SMN1; SMN2 3200/4885 |
| US-20160368918-A1 | SYK INHIBITORS | SYK, BTK, LYN | ALDH1A1 4181/4885KMT2A 930/4885SMN1; SMN2 3271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.