Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL15544885 | 1.00 | KDM4E (0.42) | KDM4EALDH1A1POLBTSHRSMN1; SMN2 | |
| Maleic Acid SCHEMBL16457674 | 0.91 | ALDH1A1 (0.47) | KDM4EALDH1A1POLBSMN1; SMN2 | |
| Fumaric Acid SCHEMBL15544596 | 0.91 | ALDH1A1 (0.47) | KDM4EALDH1A1POLBSMN1; SMN2 | |
| Fumaric Acid SCHEMBL15544522 | 0.91 | KDM4E (0.42) | KDM4EALDH1A1POLBSMN1; SMN2 | |
| Maleic Acid SCHEMBL16457848 | 0.91 | KDM4E (0.42) | KDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL15591747 | 0.90 | ALDH1A1 (0.40) | KDM4EALDH1A1POLBTSHR | |
| Fumaric Acid SCHEMBL15543696 | 0.90 | ALDH1A1 (0.42) | KDM4EALDH1A1POLBSMN1; SMN2 | |
| Maleic Acid SCHEMBL16458107 | 0.90 | ALDH1A1 (0.42) | KDM4EALDH1A1POLBSMN1; SMN2 | |
| Fumaric Acid SCHEMBL15545601 | 0.89 | HTR1A (0.45) | ALDH1A1POLB | |
| Maleic Acid SCHEMBL16457833 | 0.89 | HTR1A (0.45) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493434-B2 | Substituted indenes as medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2016-11-15 | — | — | US | claimed |
| EP-2870145-B1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2016-09-21 | — | — | EP | claimed |
| US-20150158831-A1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2015-06-11 | — | — | US | claimed |
| EP-2682391-A1 | Indene derivatives, their preparation and use as medicaments | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2014-01-08 | — | — | EP | claimed |
| US-9493434-B2 | Substituted indenes as medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2016-11-15 | — | — | US | disclosed |
| EP-2870145-B1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2016-09-21 | — | — | EP | disclosed |
| US-20150158831-A1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2015-06-11 | — | — | US | disclosed |
| EP-2682391-A1 | Indene derivatives, their preparation and use as medicaments | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2014-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158831-A1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SIGMAR1, TMEM97, OPRK1 | KDM4E 4516/4885ALDH1A1 1321/4885POLB 3114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.