Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL883438 | 0.90 | ALDH1A1 (0.65) | ALDH1A1TSHRHSD17B10ALOX15MAPK1 | |
| SCHEMBL635376 | 0.87 | ALDH1A1 (0.61) | ALDH1A1TSHRHSD17B10ALOX15MAPK1 | |
| SCHEMBL31633568 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TSHRHSD17B10ALOX15MAPK1 | |
| Trimethylammonium SCHEMBL27527350 | 0.79 | ALDH1A1 (0.36) | ALDH1A1TSHRHSD17B10MAPK1TDP1 | |
| SCHEMBL10494067 | 0.79 | TDP1 (0.41) | ALDH1A1TSHRHSD17B10TDP1HPGD | |
| SCHEMBL22041575 | 0.78 | ALDH1A1 (0.55) | ALDH1A1TSHRHSD17B10MAPK1TDP1 | |
| Fluoride Ion SCHEMBL10902267 | 0.76 | ALDH1A1 (0.61) | ALDH1A1TSHRHSD17B10ALOX15MAPK1 | |
| Ethane SCHEMBL2219423 | 0.76 | TSHR (0.39) | ALDH1A1TSHRTDP1GLACYP3A4 | |
| SCHEMBL16187039 | 0.76 | — | — | |
| SCHEMBL21208167 | 0.76 | ALDH1A1 (0.67) | ALDH1A1TSHRHSD17B10ALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999100-B2 | Method for chiral inversion of (S)-(+)-and (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and optically enriched mixtures thereof | Bial-Portela CA & S.A. (PT) | 2011-08-16 | — | — | US | claimed |
| EP-1789395-B8 | METHOD FOR CHIRAL INVERSION OF (S)-(+)- AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND OPTICALLY ENRICHED MIXTURES THEREOF | BIAL PORTELA & CA SA (PT) | 2009-08-12 | — | — | EP | claimed |
| EP-1789395-B1 | METHOD FOR CHIRAL INVERSION OF (S)-(+)- AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND OPTICALLY ENRICHED MIXTURES THEREOF | BIAL PORTELA & CA SA (PT) | 2009-01-14 | — | — | EP | claimed |
| US-20080293934-A1 | Method for Chiral Inversion of (S)-(+)-and (R)-(-)-10,11-Dihydro-10-Hydroxy-5H-Dibenz/B,F/Azepine-5-Carboxamide and Optically Enriched Mixtures Thereof | BIAL - PORTELA & CA, S.A. (PT) | 2008-11-27 | — | — | US | claimed |
| EP-1789395-A1 | METHOD FOR CHIRAL INVERSION OF (S)-(+)- AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND OPTICALLY ENRICHED MIXTURES THEREOF | Portela & CA SA (PT) | 2007-05-30 | — | — | EP | claimed |
| WO-2006005951-A1 | METHOD FOR CHIRAL INVERSION OF (S)-(+)- AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND OPTICALLY ENRICHED MIXTURES THEREOF | PORTELA & C.A. S.A. (PT) | 2006-01-19 | — | — | WO | claimed |
| CN-103502315-B | Composition and polymer | 旭化成株式会社 | 2016-08-17 | — | — | CN | disclosed |
| CN-105754099-A | Composition and polymer | 旭化成株式会社 | 2016-07-13 | — | — | CN | disclosed |
| CN-103502315-A | Composition and polymer | ASAHI KASEI CHEMICALS CORP | 2014-01-08 | — | — | CN | disclosed |
| US-8314240-B2 | Sulfonamide compounds or salts thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-20 | — | — | US | disclosed |
| US-20110201616-A1 | SULFONAMIDE COMPOUNDS OR SALTS THEREOF | ASTELLAS PHARMA INC. (JP) | 2011-08-18 | — | — | US | disclosed |
| US-7999100-B2 | Method for chiral inversion of (S)-(+)-and (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and optically enriched mixtures thereof | Bial-Portela CA & S.A. (PT) | 2011-08-16 | — | — | US | disclosed |
| EP-2305641-A1 | SULFONAMIDE COMPOUND OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2011-04-06 | — | — | EP | disclosed |
| EP-1789395-A1 | METHOD FOR CHIRAL INVERSION OF (S)-(+)- AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND OPTICALLY ENRICHED MIXTURES THEREOF | Portela & CA SA (PT) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006005951-A1 | METHOD FOR CHIRAL INVERSION OF (S)-(+)- AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND OPTICALLY ENRICHED MIXTURES THEREOF | PORTELA & C.A. S.A. (PT) | 2006-01-19 | — | — | WO | disclosed |
| EP-1461341-A1 | PROCESS FOR PREPARING A HETEROAROMATIC COMPOUND SUBSTITUTED WITH ONE OR MORE ETHER GROUPS | Agfa-Gevaert (BE) | 2004-09-29 | — | — | EP | disclosed |
| US-6734312-B2 | CONDENSING HYDROXY- GROUP OF A COMPOUND HAVING HETEROAROMATIC NUCLEUS, WITH AN ALCOHOL CONTAINING ONE OR MORE PRIMARY OR SECONDARY ALCOHOL GROUPS, OPTIONALLY USING THE REDOX COUPLE OF A TRIARYL- OR TRIALKYLPHOSPHINE AND AN AZODIOXO-COMPOUND | AGFA-GEVAERT (BE) | 2004-05-11 | — | — | US | disclosed |
| US-20030162958-A1 | Process for preparing a compound containing a heteroaromatic group with one or more ether substituents | AGFA-GEVAERT (BE) | 2003-08-28 | — | — | US | disclosed |
| WO-2003055889-A1 | PROCESS FOR PREPARING A HETEROAROMATIC COMPOUND SUBSTITUTED WITH ONE OR MORE ETHER GROUPS | AGFA-GEVAERT (BE) | 2003-07-10 | — | — | WO | disclosed |
| US-5326875-A | Alkylation of azaglycine derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293934-A1 | Method for Chiral Inversion of (S)-(+)-and (R)-(-)-10,11-Dihydro-10-Hydroxy-5H-Dibenz/B,F/Azepine-5-Carboxamide and Optically Enriched Mixtures Thereof | HTR2B, HTR5A, FHIT | ALDH1A1 1479/4885TSHR 2068/4885HSD17B10 381/4885 |
| US-20110201616-A1 | SULFONAMIDE COMPOUNDS OR SALTS THEREOF | PTGER1, PTGER2, GPER1 | ALDH1A1 614/4885TSHR 1365/4885HSD17B10 4271/4885 |
| US-20030162958-A1 | Process for preparing a compound containing a heteroaromatic group with one or more ether substituents | ADH1C, ADH1A, CYP2E1 | ALDH1A1 500/4885TSHR 1485/4885HSD17B10 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.