Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.77 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.61 |
| ▸ | KIF11 | P52732 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | ITK | Q08881 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29349799 | 0.87 | EHMT2 (1.00) | EHMT2EHMT1ITKKDM4E | |
| SCHEMBL16569005 | 0.87 | EHMT2 (1.00) | EHMT2EHMT1ITKKDM4E | |
| SCHEMBL21437365 | 0.84 | EHMT2 (0.71) | EHMT2EHMT1HDAC6ITKKDM4E | |
| SCHEMBL13983230 | 0.80 | EHMT2 (0.53) | EHMT2KIF11DRD2TBXA2RITK | |
| SCHEMBL5318309 | 0.78 | HDAC6 (0.76) | EHMT2EHMT1HDAC6KDM4EHDAC1 | |
| SCHEMBL5359797 | 0.76 | ADORA2A (0.63) | EHMT2ITK | |
| SCHEMBL2725703 | 0.76 | DRD2 (0.53) | EHMT2KIF11DRD2TBXA2RHDAC6 | |
| SCHEMBL25302284 | 0.76 | EHMT2 (1.00) | EHMT2EHMT1HDAC6ITKKDM4E | |
| SCHEMBL12707154 | 0.74 | EHMT2 (0.57) | EHMT2EHMT1HDAC6ITKKDM4E | |
| SCHEMBL21437350 | 0.74 | EHMT2 (0.65) | EHMT2EHMT1HDAC6ITKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906602-A1 | TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR (TALE) - LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1) FUSION PROTEINS | The General Hospital Corporation (US) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014059255-A1 | TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR (TALE) - LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1) FUSION PROTEINS | THE GENERAL HOSPITAL CORPORATION (US) | 2014-04-17 | — | — | WO | disclosed |