Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 9/20 | 0.89 |
| ▸ | MAPT | P10636 | 7/20 | 0.89 |
| ▸ | BACE1 | P56817 | 4/20 | 0.89 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.89 |
| ▸ | MMP9 | P14780 | 4/20 | 0.89 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.89 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.89 |
| ▸ | STAT3 | P40763 | 3/20 | 0.89 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.89 |
| ▸ | RELA | Q04206 | 3/20 | 0.89 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.89 |
| ▸ | TSHR | P16473 | 2/20 | 0.89 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.89 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.89 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.89 |
| ▸ | MAOA | P21397 | 2/20 | 0.89 |
| ▸ | MAOB | P27338 | 2/20 | 0.89 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.89 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.89 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29985625 | 1.00 | APP (0.89) | APPMAPTBACE1NFKB1MMP9 | |
| SCHEMBL29924151 | 1.00 | APP (0.89) | APPMAPTBACE1NFKB1MMP9 | |
| SCHEMBL1646542 | 1.00 | APP (0.89) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL2177792 | 0.94 | APP (0.94) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL20562725 | 0.94 | APP (0.94) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL40025 | 0.94 | APP (0.94) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL2177794 | 0.94 | APP (0.94) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL17629819 | 0.94 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL8440 | 0.94 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL8336603 | 0.94 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901618-B1 | HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE | SYMRISE GMBH & CO KG (DE) | 2009-06-17 | — | — | EP | claimed |
| US-20080227866-A1 | Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | claimed |
| WO-2022214995-A1 | PROBE DIRECTED TO ENZYME ALDH1A3 AND USE THEREOF IN THE DIAGNOSIS OF GLIOBLASTOMA | UNIVERSITA' DEGLI STUDI DEL PIEMONTE ORIENTALE "A. AVOGADRO" (IT) | 2022-10-13 | — | — | WO | disclosed |
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| US-20110111068-A1 | Inhibitors of cognitive decline | CALIFORNIA STATE UNIVERSITY CHANNEL ISLANDS FOUNDATION, CHANNEL ISLANDS ALZHEIMER'S INSTITUTE | 2011-05-12 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |
| US-7723377-B2 | Inhibitors of cognitive decline | COGNITION THERAPEUTICS, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-7723377-B2 | Inhibitors of cognitive decline | COGNITION THERAPEUTICS, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
| EP-1901618-B1 | HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE | SYMRISE GMBH & CO KG (DE) | 2009-06-17 | — | — | EP | disclosed |
| US-20080227866-A1 | Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| US-20080227866-A1 | Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| US-20080227866-A1 | Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| US-20080193574-A1 | Inhibitors Of Cognitive Decline | COGNITION THERAPEUTICS, INC. | 2008-08-14 | — | — | US | disclosed |
| US-20080193574-A1 | Inhibitors Of Cognitive Decline | COGNITION THERAPEUTICS, INC. | 2008-08-14 | — | — | US | disclosed |
| EP-1901618-A1 | HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE | Symrise GmbH & Co. KG (DE) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007003527-A1 | HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE | SYMRISE GMBH & CO. KG (DE) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | APP 2/4885MAPT 8/4885BACE1 1/4885 |
| US-20110111068-A1 | Inhibitors of cognitive decline | NAA50, NOS1, NOS2 | APP 51/4885MAPT 71/4885BACE1 7/4885 |
| US-20080227866-A1 | Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste | TAS2R1, TAS2R5, TAS2R50 | APP 3569/4885MAPT 4869/4885BACE1 2846/4885 |
| US-20080193574-A1 | Inhibitors Of Cognitive Decline | NAA50, NOS1, NOS2 | APP 51/4885MAPT 71/4885BACE1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.