Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133440 | 0.89 | FFAR4 (0.58) | HTTNPC1L3MBTL1LMNAMAPT | |
| SCHEMBL31371501 | 0.89 | FFAR4 (0.58) | HTTNPC1L3MBTL1LMNAMAPT | |
| SCHEMBL23182775 | 0.87 | KMT2A (0.55) | HTTNPC1L3MBTL1LMNAMAPT | |
| SCHEMBL17040660 | 0.87 | FFAR4 (0.60) | HTTLRRK2NPC1L3MBTL1LMNA | |
| SCHEMBL1646699 | 0.87 | FOLH1 (0.67) | LRRK2NPC1L3MBTL1LMNAMAPT | |
| SCHEMBL9832985 | 0.87 | FEN1 (0.50) | HTTLRRK2NPC1L3MBTL1LMNA | |
| SCHEMBL4415350 | 0.85 | HTT (0.75) | HTTNPC1L3MBTL1LMNAALDH1A1 | |
| SCHEMBL23809724 | 0.85 | ALDH1A1 (0.62) | HTTL3MBTL1LMNAALDH1A1TDP1 | |
| SCHEMBL1647432 | 0.84 | TDP1 (0.58) | HTTNPC1L3MBTL1LMNAMAPT | |
| SCHEMBL29707531 | 0.84 | LRRK2 (0.60) | LRRK2NPC1L3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483254-B1 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2014-08-13 | — | — | EP | disclosed |
| US-8778939-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2014-07-15 | — | — | US | disclosed |
| EP-2483254-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2012-08-08 | — | — | EP | disclosed |
| US-20120184553-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-07-19 | — | — | US | disclosed |
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | disclosed |
| US-7595337-B2 | 2-Carbonyl-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole derivatives such as 2-acetyl-8-fluoro-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole and 3S,3aS)-2-acetyl-8-chloro-7-methyl-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole that are useful for treating cancer | MERCK & CO. INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595337-B2 | 2-Carbonyl-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole derivatives such as 2-acetyl-8-fluoro-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole and 3S,3aS)-2-acetyl-8-chloro-7-methyl-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole that are useful for treating cancer | MERCK & CO. INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595337-B2 | 2-Carbonyl-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole derivatives such as 2-acetyl-8-fluoro-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole and 3S,3aS)-2-acetyl-8-chloro-7-methyl-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole that are useful for treating cancer | MERCK & CO. INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-20080182843-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-07-31 | — | — | US | disclosed |
| US-20080182843-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-07-31 | — | — | US | disclosed |
| EP-1851213-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006086358-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2006-08-17 | — | — | WO | disclosed |
| EP-1216257-B1 | COMPOUNDS FOR THE TREATMENT OF ISCHEMIA | PFIZER PROD INC (US) | 2005-12-07 | — | — | EP | disclosed |
| US-6803457-B1 | ADENOSINE RECEPTORS; FOR REDUCTION OF TISSUE DAMAGE RESULTING FROM HYPOXIA/CARDIOVASCULAR DISORDERS IN MAMMALS/HUMANS | PFIZER, INC. | 2004-10-12 | — | — | US | disclosed |
| US-20040198693-A1 | Compounds for the treatment of ischemia | DENINNO MICHAEL P (US) | 2004-10-07 | — | — | US | disclosed |
| EP-1216257-A1 | COMPOUNDS FOR THE TREATMENT OF ISCHEMIA | Pfizer Products Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023399-A1 | COMPOUNDS FOR THE TREATMENT OF ISCHEMIA | PFIZER PRODUCTS INC. (US) | 2001-04-05 | — | — | WO | disclosed |
| US-5914406-A | ENZYME INHIBITOR; USEFUL FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMAN-LA ROCHE INC. (US) | 1999-06-22 | — | — | US | disclosed |
| US-5750706-A | TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5583222-A | ANTIINFLAMMATORY AGENTS FOR TREATMENT OF SKIN DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1996-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182843-A1 | Mitotic Kinesin Inhibitors | KIF2C, KIF5B, KIF18B | HTT 1217/4885LRRK2 1983/4885NPC1 1285/4885 |
| US-20120184553-A1 | NOVEL COMPOUNDS | LRRK2, PARK7, PINK1 | HTT 110/4885LRRK2 1/4885NPC1 792/4885 |
| US-20040198693-A1 | Compounds for the treatment of ischemia | TNNI3, ADRB3, FABP3 | HTT 4102/4885LRRK2 4110/4885NPC1 3627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.