SCHEMBL16472146

SCHEMBL16472146

COc1ccc(C(OCC(O)CN)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ KIF11 P52732 11/20 0.50
▸ KCNH2 Q12809 1/20 0.48
▸ SLC6A2 P23975 1/20 0.42
▸ SLC6A4 P31645 1/20 0.42
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ TK1 P04183 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27081312 1.00 KIF11 (0.50) KIF11KCNH2SLC6A2SLC6A4MEN1
SCHEMBL14168221 0.88 KIF11 (0.53) KIF11KCNH2TK1
SCHEMBL4917240 0.88 KIF11 (0.53) KIF11KCNH2TK1
SCHEMBL19522241 0.87 SLC6A1 (0.44) KIF11KCNH2MEN1KMT2ATK1
SCHEMBL15281845 0.87 KIF11 (0.49) KIF11KCNH2MEN1KMT2ATK1
SCHEMBL3490250 0.87 KIF11 (0.49) KIF11KCNH2MEN1KMT2ATK1
SCHEMBL8633174 0.86 KIF11 (0.48) KIF11KCNH2MEN1KMT2A
SCHEMBL13160566 0.85 KIF11 (0.52) KIF11KCNH2TK1
SCHEMBL13388489 0.85 KIF11 (0.50) KIF11KCNH2
SCHEMBL21431103 0.84 TK1 (0.46) KIF11KCNH2MEN1KMT2ATK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240209018-A1 UNIVERSAL LINKER REAGENTS FOR DNA SYNTHESIS GENSCRIPT USA INC. 2024-06-27 — — US disclosed
CN-118006604-A Covalent cross-linked hammerhead ribozyme and preparation method and application thereof 兰州交通大学 2024-05-10 — — CN disclosed
EP-4313984-A1 UNIVERSAL LINKER REAGENTS FOR DNA SYNTHESIS Genscript USA Inc. (US) 2024-02-07 — — EP disclosed
CN-117222647-A Universal linker reagents for DNA synthesis 金斯瑞美国公司 2023-12-12 — — CN disclosed
US-11840691-B2 Compound and application thereof KYLONOVA (XIAMEN) BIOPHARMA CO., LTD. (CN) 2023-12-12 — — US disclosed
US-11840691-B2 Compound and application thereof KYLONOVA (XIAMEN) BIOPHARMA CO., LTD. (CN) 2023-12-12 — — US disclosed
US-20230374513-A1 NOVEL COMPOUND AND APPLICATION THEREOF KYLONOVA (XIAMEN) BIOPHARMA CO., LTD. (CN) 2023-11-23 — — US disclosed
US-20230374513-A1 NOVEL COMPOUND AND APPLICATION THEREOF KYLONOVA (XIAMEN) BIOPHARMA CO., LTD. (CN) 2023-11-23 — — US disclosed
WO-2022204102-A1 UNIVERSAL LINKER REAGENTS FOR DNA SYNTHESIS GENSCRIPT USA INC. (US) 2022-09-29 — — WO disclosed
EP-3992291-A1 NOVEL COMPOUND AND APPLICATION THEREOF Kylonova (Xiamen) Biopharma Co., Ltd. (CN) 2022-05-04 — — EP disclosed
US-20180193471-A1 ß2GPI GENE EXPRESSION-SUPPRESSING NUCLEIC ACID CONJUGATE KYOWA HAKKO KIRIN CO., LTD. (JP) 2018-07-12 — — US disclosed
EP-2248820-B1 Universal supports for oligonucleotide synthesis GLEN RES CORP (US) 2014-01-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230374513-A1 NOVEL COMPOUND AND APPLICATION THEREOF GALNT6, GALNT3, GALNT14 KIF11 4071/4885KCNH2 4855/4885SLC6A2 2365/4885
US-20180193471-A1 ß2GPI GENE EXPRESSION-SUPPRESSING NUCLEIC ACID CONJUGATE GALNT2, ST6GAL1, SLC17A5 KIF11 2975/4885KCNH2 3564/4885SLC6A2 257/4885
US-20240209018-A1 UNIVERSAL LINKER REAGENTS FOR DNA SYNTHESIS RNGTT, DTYMK, UNG KIF11 2536/4885KCNH2 3973/4885SLC6A2 2695/4885
US-11840691-B2 Compound and application thereof GALNT6, GALNT3, GALNT14 KIF11 4158/4885KCNH2 4853/4885SLC6A2 2218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback