Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.62 |
| ▸ | HTR6 | P50406 | 5/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.58 |
| ▸ | HTR1B | P28222 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | HTR1E | P28566 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | NEK2 | P51955 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647466 | 0.90 | LRRK2 (0.66) | LRRK2HTR6SIGMAR1TMEM97HTR1A | |
| SCHEMBL1315758 | 0.88 | LRRK2 (0.61) | LRRK2CYP3A4KCNH2SLCO1B1MAPT | |
| SCHEMBL23259451 | 0.86 | LRRK2 (0.62) | LRRK2HTR6HTR1ASLC6A4CYP3A4 | |
| SCHEMBL552011 | 0.86 | LRRK2 (0.62) | LRRK2CYP3A4SLCO1B1USP2MAPT | |
| SCHEMBL23259450 | 0.86 | ME2 (0.57) | LRRK2USP2MAPTKMT2A | |
| SCHEMBL15127660 | 0.81 | ALDH1A1 (0.54) | LRRK2SIGMAR1TMEM97HTR1AADRA2A | |
| SCHEMBL1316513 | 0.81 | LRRK2 (0.63) | LRRK2HTR6CYP3A4KCNH2SLCO1B1 | |
| SCHEMBL1318286 | 0.79 | LRRK2 (0.64) | LRRK2HTR6CYP3A4KCNH2SLCO1B1 | |
| SCHEMBL2478773 | 0.78 | HTR6 (0.67) | LRRK2HTR6SIGMAR1TMEM97HTR1A | |
| SCHEMBL3139131 | 0.78 | HTR6 (0.67) | LRRK2HTR6SIGMAR1TMEM97HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483254-B1 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2014-08-13 | — | — | EP | disclosed |
| US-8778939-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2014-07-15 | — | — | US | disclosed |
| EP-2483254-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2012-08-08 | — | — | EP | disclosed |
| US-20120184553-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-07-19 | — | — | US | disclosed |
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184553-A1 | NOVEL COMPOUNDS | LRRK2, PARK7, PINK1 | LRRK2 1/4885HTR6 2104/4885SIGMAR1 4516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.