SCHEMBL16478989

SCHEMBL16478989

CC1(C)CN(C(C)(C)C)CC(C)(C)N1

nearest known ligand 0.37

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 1/20 0.37
CRHR2 Q13324 1/20 0.37
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13923529 0.73 CRHBP (0.41) CRHBPCRHR2ALDH1A1
SCHEMBL9924089 0.73 CRHBP (0.41) CRHBPCRHR2ALDH1A1
SCHEMBL13093497 0.70
SCHEMBL13125355 0.70 CRHBP (0.35) CRHBPCRHR2ALDH1A1
SCHEMBL10166270 0.69 CRHBP (0.42) CRHBPCRHR2ALDH1A1
SCHEMBL14805861 0.69 CRHBP (0.38) CRHBPCRHR2ALDH1A1
SCHEMBL12127018 0.69 CRHBP (0.38) CRHBPCRHR2ALDH1A1
SCHEMBL21862624 0.69 CRHBP (0.38) CRHBPCRHR2ALDH1A1
SCHEMBL20147944 0.69 CRHBP (0.38) CRHBPCRHR2ALDH1A1
SCHEMBL10205004 0.69 CRHBP (0.38) CRHBPCRHR2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230365566-A1 HETEROCYCLIC AMIDES AND THEIR USE FOR MODULATING SPLICING REMIX THERAPEUTICS INC. 2023-11-16 US disclosed
US-20230142338-A1 THIOPHENYL DERIVATIVES USEFUL FOR MODULATING NUCLEIC ACID SPLICING REMIX THERAPEUTICS INC. 2023-05-11 US disclosed
US-9624225-B2 Quinolinyl modulators of RORγt JANSSEN PHARMACEUTICA NV (BE) 2017-04-18 US disclosed
US-9346782-B2 Alkyl linked quinolinyl modulators of RORγt JANSSEN PHARMACEUTICA NV (BE) 2016-05-24 US disclosed
US-9303015-B2 Heteroaryl linked quinolinyl modulators of RORγt JANSSEN PHARMACEUTICA NV (BE) 2016-04-05 US disclosed
US-9221804-B2 Secondary alcohol quinolinyl modulators of RORγt JANSSEN PHARMACEUTICA NV (BE) 2015-12-29 US disclosed
US-20150111870-A1 QUINOLINYL MODULATORS OF RORyt JOHNSON & JOHNSON (US) 2015-04-23 US disclosed
US-20150105372-A1 SECONDARY ALCOHOL QUINOLINYL MODULATORS OF RORyt JANSSEN PHARMACEUTICA NV (BE) 2015-04-16 US disclosed
US-20150105369-A1 ALKYL LINKED QUINOLINYL MODULATORS OF RORyt JANSSEN PHARMACEUTICA NV (BE) 2015-04-16 US disclosed
US-20140107096-A1 HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt JANSSEN PHARMACEUTICA NV (BE) 2014-04-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230365566-A1 HETEROCYCLIC AMIDES AND THEIR USE FOR MODULATING SPLICING RBM17, HNRNPA1, HNRNPAB CRHBP 658/4885CRHR2 2062/4885ALDH1A1 1569/4885
US-20140107096-A1 HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt RORC, RORA, RORB CRHBP 2314/4885CRHR2 526/4885ALDH1A1 1069/4885
US-20150111870-A1 QUINOLINYL MODULATORS OF RORyt RORC, RORA, RORB CRHBP 2080/4885CRHR2 651/4885ALDH1A1 1295/4885
US-20150105372-A1 SECONDARY ALCOHOL QUINOLINYL MODULATORS OF RORyt RORC, RORA, RORB CRHBP 1984/4885CRHR2 664/4885ALDH1A1 144/4885
US-20230142338-A1 THIOPHENYL DERIVATIVES USEFUL FOR MODULATING NUCLEIC ACID SPLICING SNRPA, NSUN3, NSUN2 CRHBP 842/4885CRHR2 4132/4885ALDH1A1 2294/4885
US-20150105369-A1 ALKYL LINKED QUINOLINYL MODULATORS OF RORyt RORC, RORA, RORB CRHBP 2527/4885CRHR2 677/4885ALDH1A1 958/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.