Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22620411 | 0.78 | PDE2A (0.41) | PDE2APTPN5MAPTKIF11ALDH1A1 | |
| SCHEMBL31135808 | 0.75 | CES2 (0.46) | CES2PDE2APTPN5METAP2CYP3A4 | |
| SCHEMBL7057873 | 0.75 | CES2 (0.42) | CES2PDE2APTPN5METAP2TSHR | |
| SCHEMBL12535901 | 0.75 | CES2 (0.46) | CES2PDE2APTPN5METAP2CYP3A4 | |
| SCHEMBL28770910 | 0.75 | PDE2A (0.50) | CES2PDE2APTPN5METAP2TSHR | |
| SCHEMBL22620302 | 0.73 | ADRA2A (0.40) | PDE2APTPN5NPSR1KIF11ALDH1A1 | |
| SCHEMBL20052480 | 0.73 | L3MBTL1 (0.44) | LRRK2MAPK1MAPTNPSR1CYP3A4 | |
| SCHEMBL6061078 | 0.72 | CES2 (0.56) | CES2PDE2APTPN5TSHRMAPK1 | |
| SCHEMBL18979040 | 0.72 | CES2 (0.40) | CES2PDE2AMETAP2LRRK2MAPT | |
| SCHEMBL31571863 | 0.72 | ALDH1A1 (0.41) | CES2TSHRMAPK1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238152-B1 | PROCESSES FOR PREPARATION OF DUTASTERIDE | GADOR SA (AR) | 2015-02-18 | — | — | EP | disclosed |