Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RNF4 | P78317 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106756 | 0.85 | KEAP1 (0.55) | TSPOTSHRKMT2ASMN1; SMN2KEAP1 | |
| SCHEMBL30278608 | 0.82 | TSPO (0.48) | TSPOTSHRMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL15984777 | 0.81 | SMN1; SMN2 (0.62) | TSPOTSHRMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL1607897 | 0.81 | MEN1 (0.42) | TSPOKMT2ASMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL28431105 | 0.79 | MMP2 (0.45) | KMT2ABCL2A1ALDH1A1 | |
| SCHEMBL3022089 | 0.79 | ALDH1A1 (0.40) | TSHRKMT2ASMN1; SMN2BCL2A1ALDH1A1 | |
| SCHEMBL28432352 | 0.79 | ALDH1A1 (0.40) | MAPTKMT2ASMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL6511106 | 0.79 | ALDH1A1 (0.50) | TSPOTSHRKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14756133 | 0.77 | TSPO (0.49) | TSPOTSHRMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL8712793 | 0.77 | TSPO (0.49) | TSPOTSHRMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394990-A1 | INDOLINE DERIVATIVES | Kyoto University (JP) | 2011-12-14 | — | — | EP | disclosed |
| US-20110294850-A1 | INDOLINE DERIVATIVES | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294850-A1 | INDOLINE DERIVATIVES | BCHE, ACHE, INMT | TSPO 3994/4885TSHR 1031/4885MAPT 2067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.