Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.38 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16512391 | 0.81 | KEAP1 (0.44) | KEAP1NFE2L2SMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL16498230 | 0.76 | KEAP1 (0.44) | KEAP1NFE2L2SMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL16499203 | 0.76 | L3MBTL1 (0.46) | SMN1; SMN2KMT2AL3MBTL1KDM4ETDP1 | |
| SCHEMBL16498257 | 0.76 | CHEK1 (0.47) | KEAP1NFE2L2SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL16499092 | 0.74 | CHEK1 (0.48) | KEAP1NFE2L2SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL19465582 | 0.74 | CFTR (0.54) | KDM4ECFTRRPA1ALDH1A1 | |
| SCHEMBL16498311 | 0.74 | CYP2C19 (0.50) | SMN1; SMN2KMT2AL3MBTL1MEN1RPA1 | |
| SCHEMBL3494109 | 0.72 | POLB (0.55) | KEAP1NFE2L2SMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL27805034 | 0.72 | LMNA (0.48) | KEAP1NFE2L2SMN1; SMN2KMT2ALMNA | |
| SCHEMBL29042737 | 0.72 | NPC1 (0.47) | KEAP1NFE2L2SMN1; SMN2L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011153588-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2011-12-15 | — | — | WO | disclosed |
| WO-2011153588-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2011-12-15 | — | — | WO | disclosed |