Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisolone Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 13/20 | 0.75 |
| ▸ | PGR | P06401 | 4/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | AR | P10275 | 2/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.75 |
| ▸ | TNF | P01375 | 1/20 | 0.75 |
| ▸ | IL6 | P05231 | 1/20 | 0.75 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.75 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.75 |
| ▸ | GLUL | P15104 | 1/20 | 0.75 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.75 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone Phosphoric Acid SCHEMBL1270166 | 1.00 | PGR (0.77) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| Prednisolone Phosphoric Acid SCHEMBL23563 | 1.00 | PGR (0.77) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| Prednisolone Phosphoric Acid SCHEMBL3360895 | 0.97 | NR3C1 (0.81) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| Prednisolone Phosphoric Acid SCHEMBL15568676 | 0.95 | PGR (0.75) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| SCHEMBL20451346 | 0.94 | PGR (0.81) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| Prednisolone Phosphoric Acid SCHEMBL24622433 | 0.92 | PGR (0.78) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| Prednisolone Phosphoric Acid SCHEMBL136773 | 0.92 | PGR (0.78) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| Prednisolone Phosphoric Acid SCHEMBL21152848 | 0.92 | PGR (0.78) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| Prednisolone Phosphoric Acid SCHEMBL21152533 | 0.92 | PGR (0.78) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| Prednisolone Phosphoric Acid SCHEMBL13130881 | 0.92 | PGR (0.78) | PGRHIF1ANR3C1HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114441663-A | Method for screening protein positive compounds by using solid phase microextraction affinity selection mass spectrum | 中国科学院上海药物研究所 | 2022-05-06 | — | — | CN | disclosed |
| CN-104610414-B | A kind of production technology of Inflamase | 河南利华制药有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-105294810-A | Process for producing high-standard prednisolone sodium phosphate | Henan lihua pharmaceutical co ltd | 2016-02-03 | — | — | CN | disclosed |
| CN-104610414-A | Prednisolone sodium phosphate production technology | Henan lihua pharmaceutical co ltd | 2015-05-13 | — | — | CN | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20100222311-A1 | SOLID FORMULATIONS OF CRYSTALLINE COMPOUNDS | PURDUE RESEARCH FOUNDATION (US) | 2010-09-02 | — | — | US | disclosed |