Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2501365 | 0.78 | LMNA (0.46) | HTTSMN1; SMN2NPC1LMNAMAPT | |
| SCHEMBL15471187 | 0.77 | MMP13 (0.65) | HTTSMN1; SMN2LMNARAB9AALDH1A1 | |
| SCHEMBL8705771 | 0.76 | KIF11 (0.46) | HTTSMN1; SMN2NPC1LMNAMAPT | |
| SCHEMBL2501471 | 0.76 | LMNA (0.53) | HTTSMN1; SMN2NPC1LMNAMAPT | |
| SCHEMBL6583697 | 0.75 | LMNA (0.44) | HTTSMN1; SMN2NPC1LMNAMAPT | |
| SCHEMBL12935919 | 0.74 | MTNR1A (0.60) | HTTSMN1; SMN2RAB9AMTNR1AMTNR1B | |
| SCHEMBL6585390 | 0.74 | LMNA (0.46) | HTTSMN1; SMN2NPC1LMNAMAPT | |
| SCHEMBL3435840 | 0.73 | KIF11 (0.46) | SMN1; SMN2NPC1LMNAMAPTMAPK1 | |
| SCHEMBL25460833 | 0.73 | NPC1 (0.47) | HTTSMN1; SMN2NPC1LMNAMAPT | |
| SCHEMBL11499757 | 0.73 | CHRM2 (0.45) | HTTSMN1; SMN2NPC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671869-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2015-11-04 | — | — | EP | disclosed |
| CN-103339109-B | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC | 2015-04-29 | — | — | CN | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| EP-2671869-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2013-12-11 | — | — | EP | disclosed |
| US-20130317010-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2013-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130317010-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE | HTR5A, HTR2A, HTR1A | HTT 155/4885SMN1; SMN2 4569/4885NPC1 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.