Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 2/20 | 0.36 |
| ▸ | CD44 | P16070 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518181 | 0.86 | HTR7 (0.43) | HTR7PRCPNISCHHTR2CHTR2A | |
| SCHEMBL16518148 | 0.86 | PNMT (0.45) | HTR7PRCPHTR2CHTR2AHTR2B | |
| SCHEMBL16518157 | 0.86 | PNMT (0.45) | HTR7PRCPHTR2CHTR2AHTR2B | |
| SCHEMBL16518153 | 0.83 | HTR5A (0.41) | HTR7PRCPHTR2CHTR2AHTR2B | |
| SCHEMBL16518134 | 0.82 | PARP1 (0.41) | HTR7HTR2CHTR2AHTR2BPNMT | |
| SCHEMBL16518170 | 0.80 | HTR5A (0.41) | HTR7PRCPHTR2CHTR2AHTR2B | |
| SCHEMBL2258843 | 0.80 | HTR2C (0.47) | HTR7PRCPNISCHHTR2CHTR2A | |
| SCHEMBL16518159 | 0.78 | CDC7 (0.39) | HTR7HTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL1198541 | 0.78 | HTR2C (0.46) | HTR7NISCHHTR2CHTR2AHTR2B | |
| SCHEMBL16518156 | 0.77 | PNMT (0.46) | PRCPHTR2CHTR2AHTR2BPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671869-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |