Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.88 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.88 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.88 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.88 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.88 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.88 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.88 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.88 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.88 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.88 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.88 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 3/20 | 0.79 |
| ▸ | MEN1 | O00255 | 3/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimebutine SCHEMBL14273976 | 0.93 | OPRM1 (1.00) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Trimebutine SCHEMBL25705 | 0.93 | OPRM1 (1.00) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Trimebutine SCHEMBL7428847 | 0.92 | OPRM1 (0.98) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Trimebutine SCHEMBL67225 | 0.88 | ALDH1A1 (1.00) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Trimebutine SCHEMBL1652810 | 0.88 | ALDH1A1 (1.00) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Trimebutine SCHEMBL5011979 | 0.88 | ALDH1A1 (1.00) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| Trimebutine SCHEMBL28274910 | 0.88 | ALDH1A1 (1.00) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| SCHEMBL23977102 | 0.86 | OPRM1 (0.81) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| SCHEMBL31432918 | 0.85 | OPRM1 (0.69) | OPRM1OPRD1PDE4DNR1I2CHRM2 | |
| SCHEMBL14317655 | 0.85 | OPRM1 (0.83) | OPRM1OPRD1PDE4DNR1I2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150057316-A1 | NOVEL SULFONATE-BASED TRIMEBUTINE SALTS | GICARE PHARMA INC. (CA) | 2015-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057316-A1 | NOVEL SULFONATE-BASED TRIMEBUTINE SALTS | TBK1, SI, TRIM59 | OPRM1 476/4885OPRD1 76/4885PDE4D 3034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.