Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1201347 | 1.00 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3KMT2AMLNR | |
| SCHEMBL98019 | 1.00 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3KMT2AMLNR | |
| Methylamine SCHEMBL6327312 | 0.97 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3KMT2AMLNR | |
| SCHEMBL4139336 | 0.92 | KMT2A (0.46) | SLC6A2SLC6A4SLC6A3KMT2AMLNR | |
| SCHEMBL12546727 | 0.88 | KMT2A (0.44) | SLC6A2SLC6A4SLC6A3KMT2AMLNR | |
| SCHEMBL12546791 | 0.88 | KMT2A (0.44) | SLC6A2SLC6A4SLC6A3KMT2AMLNR | |
| SCHEMBL13536715 | 0.86 | KMT2A (0.46) | SLC6A2SLC6A4SLC6A3KMT2AMLNR | |
| Mandelic Acid SCHEMBL6378790 | 0.85 | LMNA (0.46) | SLC6A2SLC6A4SLC6A3KMT2AMLNR | |
| Mandelic Acid SCHEMBL6376919 | 0.85 | LMNA (0.46) | SLC6A2SLC6A4SLC6A3KMT2AMLNR | |
| SCHEMBL14353971 | 0.83 | KMT2A (0.46) | SLC6A2SLC6A4SLC6A3KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 411 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12365927-B2 | Engineered ketoreductase polypeptides | CODEXIS, INC. (US) | 2025-07-22 | — | — | US | claimed |
| CN-119685420-A | Method for preparing (S) -3-methylamino-1- (2-thienyl) -1-propanol by asymmetric reduction of alcohol dehydrogenase | 瑞博(苏州)制药有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-117645597-A | Method for synthesizing key chiral intermediate of duloxetine by asymmetric form hydroamination | 江苏恒盛药业有限公司 | 2024-03-05 | — | — | CN | claimed |
| US-20230104779-A1 | ENGINEERED KETOREDUCTASE POLYPEPTIDES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2023-04-06 | — | — | US | claimed |
| US-11512332-B2 | Engineered ketoreductase polypeptides | CODEXIS, INC. (US) | 2022-11-29 | — | — | US | claimed |
| CN-112126663-A | Production process of duloxetine | 浙江拓普药业股份有限公司 | 2020-12-25 | — | — | CN | claimed |
| US-20200340025-A1 | ENGINEERED KETOREDUCTASE POLYPEPTIDES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2020-10-29 | — | — | US | claimed |
| US-10752926-B2 | Engineered ketoreductase polypeptides | CODEXIS, INC. (US) | 2020-08-25 | — | — | US | claimed |
| US-10724008-B2 | Ketoreductases | C-LECTA GMBH (DE) | 2020-07-28 | — | — | US | claimed |
| CN-109535123-A | A kind of preparation method of (S) -3- methylamino -1- (2- thienyl) -1- propyl alcohol | 凯瑞斯德生化(苏州)有限公司 | 2019-03-29 | — | — | CN | claimed |
| US-20060063943-A1 | Process for preparing optically active 3-(methylamino)-1-(2-thienyl) propan-1-ol and intermediates for preparation | YAMAKAWA CHEMICAL INDUSTRY CO., LTD. (JP) | 2006-03-23 | — | — | US | claimed |
| US-20050282821-A1 | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives | CEPHALON FRANCE (FR) | 2005-12-22 | — | — | US | claimed |
| EP-1589016-A1 | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives | CEPHALON FRANCE (FR) | 2005-10-26 | — | — | EP | claimed |
| CN-1678562-A | Method for the enantioselective hydrogenation of amino alcohols | MERCK PATENT GMBH (DE) | 2005-10-05 | — | — | CN | claimed |
| US-20050171360-A1 | Preparation of n-methyl-3-hydroxy- 3-(2-thienyl)propylamine via novel thiophene derivatives containing carbamate groups as intermediates | DEGUSSA AG (DE) | 2005-08-04 | — | — | US | claimed |
| WO-2005033094-A2 | METHODS FOR THE PRODUCTION OF 3-METHYLAMINO-1-(THIENE-2-YL)-PROPANE-1-OL | BASF AKTIENGESELLSCHAFT (DE) | 2005-04-14 | — | — | WO | claimed |
| EP-1506965-A1 | PROPANOLAMINE DERIVATIVES, PROCESS FOR PREPARATION OF 3-N-METHYLAMINO-1-(2-THIENYL)-1-PROPANOLS AND PROCESS FOR PREPARATION OF PROPANOLAMINE DERIVATIVES | Mitsubishi Rayon Co., Ltd. (JP) | 2005-02-16 | — | — | EP | claimed |
| EP-1476439-A1 | PREPARATION OF N-METHYL-3-HYDROXY- 3-(2-THIENYL)PROPYLAMINE VIA NOVEL THIOPHENE DERIVATIVES CONTAINING CARBAMATE GROUPS AS INTERMEDIATES | Degussa AG (DE) | 2004-11-17 | — | — | EP | claimed |
| CN-1497048-A | Method for preparing 3-heteroarylradical-3-hydroxy-propionic acid derivative | 拜尔公司 | 2004-05-19 | — | — | CN | claimed |
| WO-2003070720-A1 | PREPARATION OF N-METHYL-3-HYDROXY- 3-(2-THIENYL)PROPYLAMINE VIA NOVEL THIOPHENE DERIVATIVES CONTAINING CARBAMATE GROUPS AS INTERMEDIATES | DEGUSSA AG (DE) | 2003-08-28 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282821-A1 | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives | HTR1A, HTR2A, HTR5A | SLC6A2 86/4885SLC6A4 44/4885SLC6A3 12/4885 |
| US-20060063943-A1 | Process for preparing optically active 3-(methylamino)-1-(2-thienyl) propan-1-ol and intermediates for preparation | TPMT, HTR1A, TPH1 | SLC6A2 91/4885SLC6A4 40/4885SLC6A3 132/4885 |
| US-20050171360-A1 | Preparation of n-methyl-3-hydroxy- 3-(2-thienyl)propylamine via novel thiophene derivatives containing carbamate groups as intermediates | HTR3C, PNMT, HTR2C | SLC6A2 60/4885SLC6A4 21/4885SLC6A3 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.