Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16553825 | 0.78 | FDPS (0.36) | FBP1ALDH1A1 | |
| SCHEMBL20898577 | 0.76 | ELANE (0.43) | MEN1CYP1A2CYP2C19KMT2A | |
| SCHEMBL28101005 | 0.74 | NNMT (0.49) | NNMTKDM4EALDH1A1MKNK1MKNK2 | |
| SCHEMBL359159 | 0.73 | SMN1; SMN2 (0.43) | KDM4EALDH1A1MEN1CYP1A2KMT2A | |
| SCHEMBL3718331 | 0.73 | SMN1; SMN2 (0.43) | KDM4EALDH1A1MEN1CYP1A2KMT2A | |
| Hydrochloric Acid SCHEMBL9641232 | 0.72 | SMN1; SMN2 (0.42) | KDM4EALDH1A1MEN1CYP1A2KMT2A | |
| SCHEMBL17933370 | 0.68 | FDPS (0.38) | FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL16553709 | 0.66 | — | — | |
| SCHEMBL8409101 | 0.66 | ALDH1A1 (0.52) | KDM4EALDH1A1HSD17B10MEN1CYP1A2 | |
| SCHEMBL5838870 | 0.65 | GRIN2D (0.33) | CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10053476-B2 | Phosphohistidine and phosphotyrosine analogues | UNIVERSITY OF SHEFFIELD (GB) | 2018-08-21 | — | — | US | disclosed |
| EP-2976346-B1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | UNIV SHEFFIELD (GB) | 2017-02-22 | — | — | EP | disclosed |
| US-20160207948-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | UNIVERSITY OF SHEFFIELD (GB) | 2016-07-21 | — | — | US | disclosed |
| EP-2976346-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | University of Sheffield (GB) | 2016-01-27 | — | — | EP | disclosed |
| WO-2015033120-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | UNIVERSITY OF SHEFFIELD (GB) | 2015-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207948-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | HRH3, CYTH3, CYTH2 | NNMT 1280/4885FBP1 1675/4885KDM4E 625/4885 |
| US-10053476-B2 | Phosphohistidine and phosphotyrosine analogues | HRH3, CYTH3, CYTH2 | NNMT 1303/4885FBP1 1547/4885KDM4E 593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.