Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | MMP16 | P51512 | 2/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2209026 | 0.87 | PTGS2 (0.44) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL6713912 | 0.77 | CA12 (0.53) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL6723569 | 0.77 | CA12 (0.53) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL9235115 | 0.77 | SIRT1 (0.47) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL2204495 | 0.77 | PTGS2 (0.56) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL18797642 | 0.75 | PTGS2 (0.50) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL7386202 | 0.74 | CXCL8 (0.45) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL14097981 | 0.73 | MMP2 (0.39) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL10685152 | 0.73 | KMT2A (0.49) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL1343676 | 0.71 | PTGS2 (0.50) | MMP2MMP9MMP8MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3043784-A1 | ARYL ETHERS AND USES THEREOF | Peloton Therapeutics, Inc. (US) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015035223-A1 | ARYL ETHERS AND USES THEREOF | PELOTON THERAPEUTICS, INC. (US) | 2015-03-12 | — | — | WO | disclosed |