Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | MMP12 | P39900 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | MMP14 | P50281 | 2/20 | 0.44 |
| ▸ | MMP16 | P51512 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16556233 | 0.87 | MMP2 (0.41) | PTGS2CXCL8MMP2MMP9MMP8 | |
| SCHEMBL7386202 | 0.85 | CXCL8 (0.45) | PTGS2CXCL8MMP2MMP9MMP8 | |
| SCHEMBL9493980 | 0.82 | SRC (0.45) | KMT2AMEN1GAAALDH1A1PKM | |
| SCHEMBL6713912 | 0.81 | CA12 (0.53) | PTGS2CXCL8MMP2MMP9MMP8 | |
| SCHEMBL6723569 | 0.81 | CA12 (0.53) | PTGS2CXCL8MMP2MMP9MMP8 | |
| SCHEMBL9235115 | 0.81 | SIRT1 (0.47) | PTGS2CXCL8MMP2MMP9MMP8 | |
| SCHEMBL2204495 | 0.81 | PTGS2 (0.56) | PTGS2CXCL8MMP2MMP9MMP8 | |
| SCHEMBL6829891 | 0.81 | LMNA (0.47) | KMT2AMEN1GAAALDH1A1PKM | |
| SCHEMBL18797642 | 0.79 | PTGS2 (0.50) | PTGS2CXCL8MMP2MMP9MMP8 | |
| SCHEMBL14097981 | 0.78 | MMP2 (0.39) | PTGS2CXCL8MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791268-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8642775-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-02-04 | — | — | US | disclosed |
| US-20110184020-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | GRUENENTHAL GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
| EP-2146962-A2 | NOVEL VANILLOID RECEPTOR LIGANDS AND THE USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICALS | Grünenthal GmbH (DE) | 2010-01-27 | — | — | EP | disclosed |
| US-20080262039-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | GRUENENTHAL GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
| WO-2008125337-A2 | NOVEL VANILLOID RECEPTOR LIGANDS AND THE USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICALS | Grünenthal GmbH (DE) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262039-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | TRPV1, TRPV2, TRPV3 | PTGS2 227/4885CXCL8 913/4885MMP2 3298/4885 |
| US-20110184020-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | TRPV1, TRPV2, TRPV3 | PTGS2 227/4885CXCL8 913/4885MMP2 3298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.