Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.35 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.35 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 2/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11878033 | 0.80 | ACHE (0.50) | ACHEMAOAAKR1B1CES1MAPK14 | |
| SCHEMBL21174888 | 0.80 | ACHE (0.50) | ACHEMAOAAKR1B1CES1MAPK14 | |
| SCHEMBL15143455 | 0.78 | ACHE (0.47) | ACHEMAOAAKR1B1CES1MAPK14 | |
| SCHEMBL9171936 | 0.77 | MAPT (0.41) | ACHECES1BCHES100A4ALDH1A1 | |
| SCHEMBL15143211 | 0.76 | ALDH1A1 (0.49) | ACHEMAOAAKR1B1CES1ALDH1A1 | |
| SCHEMBL21259308 | 0.76 | ACHE (0.50) | ACHEMAOAAKR1B1CES1MAPK14 | |
| SCHEMBL10369148 | 0.75 | MAOB (0.41) | MAOACES1BCHEALDH1A1NSD2 | |
| SCHEMBL10369146 | 0.75 | MAOB (0.41) | MAOACES1BCHEALDH1A1NSD2 | |
| Hydrochloric Acid SCHEMBL10513970 | 0.75 | MAPT (0.40) | ACHECES1BCHES100A4ALDH1A1 | |
| SCHEMBL86279 | 0.73 | ACHE (0.59) | ACHEMAOAAKR1B1CES1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210186969-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Biopharma, Inc. (US) | 2021-06-24 | — | — | US | disclosed |
| US-10980805-B2 | Aza-pyridone compounds and uses thereof | Janssen Biopharma, Inc. (US) | 2021-04-20 | — | — | US | disclosed |
| EP-3778603-A1 | 7,8-DIHYDRO-3H-PYRAZINO[1,2-B]PYRIDAZINE-3,5(6H)-DIONE COMPOUNDS AND USES THEREOF | Janssen BioPharma, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3030566-B1 | 7,8-DIHYDRO-3H-PYRAZINO[1,2-B]PYRIDAZINE-3,5(6H)-DIONE COMPOUNDS AND USES THEREOF | JANSSEN BIOPHARMA INC (US) | 2020-07-08 | — | — | EP | disclosed |
| US-10702523-B2 | AZA-pyridone compounds and uses thereof | Janssen Biopharma, Inc. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20200030328-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Biopharma, Inc. (US) | 2020-01-30 | — | — | US | disclosed |
| US-20190314373-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. (US) | 2019-10-17 | — | — | US | disclosed |
| US-10251882-B2 | Aza-pyridone compounds and uses thereof | ALIOS BIOPHARMA, INC. (US) | 2019-04-09 | — | — | US | disclosed |
| US-20160228438-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. | 2016-08-11 | — | — | US | disclosed |
| US-20160228438-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. | 2016-08-11 | — | — | US | disclosed |
| US-9328119-B2 | AZA-pyridone compounds and uses thereof | ALIOS BIOPHARMA, INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-9328119-B2 | AZA-pyridone compounds and uses thereof | ALIOS BIOPHARMA, INC. (US) | 2016-05-03 | — | — | US | disclosed |
| WO-2015038655-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. (US) | 2015-03-19 | — | — | WO | disclosed |
| US-20150072982-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Pharmaceuticals, Inc. | 2015-03-12 | — | — | US | disclosed |
| US-20150072982-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Pharmaceuticals, Inc. | 2015-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200030328-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | ACHE 178/4885MAOA 132/4885AKR1B1 1902/4885 |
| US-10980805-B2 | Aza-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | ACHE 178/4885MAOA 132/4885AKR1B1 1902/4885 |
| US-20190314373-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | ACHE 178/4885MAOA 132/4885AKR1B1 1902/4885 |
| US-10251882-B2 | Aza-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | ACHE 178/4885MAOA 132/4885AKR1B1 1902/4885 |
| US-20210186969-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | ACHE 178/4885MAOA 132/4885AKR1B1 1902/4885 |
| US-10702523-B2 | AZA-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | ACHE 178/4885MAOA 132/4885AKR1B1 1902/4885 |
| US-20160228438-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | ACHE 178/4885MAOA 132/4885AKR1B1 1902/4885 |
| US-20150072982-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | ACHE 178/4885MAOA 132/4885AKR1B1 1902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.