Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21174888 | 0.76 | ACHE (0.50) | ACHEAKR1B1MAOAALDH1A1CES1 | |
| SCHEMBL11878033 | 0.76 | ACHE (0.50) | ACHEAKR1B1MAOAALDH1A1CES1 | |
| SCHEMBL16559335 | 0.76 | ACHE (0.50) | ACHEAKR1B1MAOAALDH1A1CES1 | |
| SCHEMBL15143211 | 0.76 | ALDH1A1 (0.49) | ACHEAKR1B1MAOAALDH1A1CES1 | |
| SCHEMBL15143219 | 0.71 | ALDH1A1 (0.38) | ACHEMAOAALDH1A1PDCD1CD274 | |
| SCHEMBL11709904 | 0.71 | AKR1B1 (0.74) | ACHEAKR1B1MAOAALDH1A1CES1 | |
| SCHEMBL17715427 | 0.70 | MAOA (0.55) | MAOAALDH1A1CES1BCHEPDCD1 | |
| SCHEMBL18149370 | 0.70 | AURKA (0.32) | ACHE | |
| SCHEMBL86279 | 0.70 | ACHE (0.59) | ACHEAKR1B1MAOAALDH1A1CES1 | |
| SCHEMBL31123671 | 0.70 | ACHE (0.59) | ACHEAKR1B1MAOAALDH1A1CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190248785-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO., LTD. (JP) | 2019-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190248785-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | PREP, UNG, DPP4 | ACHE 1599/4885AKR1B1 1860/4885MAOA 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.