Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 4/20 | 0.44 |
| ▸ | FABP4 | P15090 | 4/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16563847 | 0.82 | MEN1 (0.47) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL16563767 | 0.80 | ALOX15 (0.44) | ALOX15RAB9A | |
| SCHEMBL16564046 | 0.78 | P2RX7 (0.47) | MEN1KMT2AALOX15ALDH1A1NPC1 | |
| SCHEMBL16563497 | 0.77 | PTGES (0.39) | MEN1KMT2AALOX15ALDH1A1NPC1 | |
| SCHEMBL16563900 | 0.76 | MAPT (0.50) | MEN1KMT2AHPGDLMNATP53 | |
| SCHEMBL16563648 | 0.76 | MAPT (0.52) | RAB9ANPSR1 | |
| SCHEMBL16563623 | 0.76 | ALOX15 (0.42) | MEN1KMT2AALOX15ALDH1A1NPC1 | |
| SCHEMBL16563581 | 0.75 | POLB (0.52) | ALOX15HPGDHTTLMNA | |
| SCHEMBL16564040 | 0.75 | ORAI1 (0.52) | MEN1KMT2AALOX15NPC1RAB9A | |
| SCHEMBL16564132 | 0.74 | KMT2A (0.44) | MEN1KMT2AALOX15ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |