Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 9/20 | 0.45 |
| ▸ | CA2 | P00918 | 9/20 | 0.45 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16563791 | 0.78 | POLB (0.53) | POLBMAPTLMNAATM | |
| SCHEMBL16564040 | 0.76 | ORAI1 (0.52) | POLBHTTMAPK1LMNAGLA | |
| SCHEMBL16563767 | 0.75 | ALOX15 (0.44) | ALOX15 | |
| SCHEMBL16563605 | 0.75 | MEN1 (0.45) | HTTLMNAHPGDALOX15 | |
| SCHEMBL16563623 | 0.74 | ALOX15 (0.42) | POLBHTTMAPTMAPK1LMNA | |
| SCHEMBL16564132 | 0.73 | KMT2A (0.44) | POLBHTTMAPTLMNAGLA | |
| SCHEMBL16563900 | 0.73 | MAPT (0.50) | POLBMAPTMAPK1LMNAHPGD | |
| SCHEMBL16564046 | 0.73 | P2RX7 (0.47) | POLBMAPK1LMNAATMALOX15 | |
| SCHEMBL16563915 | 0.73 | CYP1A2 (0.54) | POLBPYGLL3MBTL1 | |
| SCHEMBL16563497 | 0.72 | PTGES (0.39) | POLBHTTMAPTLMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |