Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16564040 | 0.84 | ORAI1 (0.52) | ALOX15ORAI1MAPK1POLBKMT2A | |
| SCHEMBL16563900 | 0.80 | MAPT (0.50) | MAPTMAPK1POLBKMT2AKDM4E | |
| SCHEMBL16563915 | 0.77 | CYP1A2 (0.54) | POLBKMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL16563947 | 0.77 | HDAC8 (0.47) | POLBKMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL16563778 | 0.76 | KMT2A (0.43) | POLBKMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL16563767 | 0.76 | ALOX15 (0.44) | ALOX15RAB9A | |
| SCHEMBL16563605 | 0.76 | MEN1 (0.45) | ALOX15KMT2AALDH1A1MEN1HPGD | |
| SCHEMBL16563791 | 0.75 | POLB (0.53) | MAPTPOLBKMT2AALDH1A1KDM4E | |
| SCHEMBL16563581 | 0.74 | POLB (0.52) | ALOX15MAPTMAPK1POLBHPGD | |
| SCHEMBL16563611 | 0.74 | POLB (0.42) | POLBKMT2AALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |