Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | PSIP1 | O75475 | 2/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 5/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10455034 | 0.87 | PSIP1 (0.74) | CA2PSIP1KMT2AGAALMNA | |
| Phenol SCHEMBL28291911 | 0.84 | PSIP1 (0.78) | CA2PSIP1KMT2AGAACA12 | |
| SCHEMBL2646220 | 0.84 | CA2 (0.53) | CA2PSIP1ENPP2KMT2AGAA | |
| SCHEMBL26966824 | 0.82 | ENPP2 (0.56) | CA2PSIP1ENPP2KMT2AGAA | |
| SCHEMBL8355889 | 0.82 | CA2 (0.75) | CA2ENPP2KMT2AGAALMNA | |
| SCHEMBL7283306 | 0.81 | ALDH1A1 (0.53) | CA2ENPP2KMT2ALMNACA12 | |
| Morpholine SCHEMBL27847416 | 0.80 | KMT2A (0.43) | CA2PSIP1ENPP2KMT2AGAA | |
| SCHEMBL1347874 | 0.79 | THRA (0.54) | CA2ENPP2KMT2ALMNAESR1 | |
| SCHEMBL10437234 | 0.78 | CA2 (0.57) | CA2ENPP2KMT2AGAALMNA | |
| SCHEMBL10823106 | 0.78 | CA2 (0.57) | CA2ENPP2KMT2AGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522926-B2 | Activators of glucokinase | METABASIS THERAPEUTICS, INC. (US) | 2016-12-20 | — | — | US | claimed |
| CN-101821276-B | Novel glucokinase activators | 症变治疗公司 | 2016-08-31 | — | — | CN | claimed |
| US-20150119365-A1 | NOVEL ACTIVATORS OF GLUCOKINASE | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2015-04-30 | — | — | US | claimed |
| EP-2185570-B1 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS INC (US) | 2014-03-19 | — | — | EP | claimed |
| US-20110294758-A1 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS, INC. (US) | 2011-12-01 | — | — | US | claimed |
| JP-2010536773-A | — | — | 2010-12-02 | — | — | JP | claimed |
| CN-101821276-A | Novel glucokinase activators | METABASIS THERAPEUTICS INC | 2010-09-01 | — | — | CN | claimed |
| EP-2185570-A2 | NOVEL ACTIVATORS OF GLUCOKINASE | Metabasis Therapeutics, Inc. (US) | 2010-05-19 | — | — | EP | claimed |
| WO-2009023718-A2 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS, INC. (US) | 2009-02-19 | — | — | WO | claimed |
| US-20250145621-A1 | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | INCYTE HOLDINGS CORPORATION | 2025-05-08 | — | — | US | disclosed |
| US-12227502-B2 | 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c] pyridin-7(6H)-ones as inhibitors of BET proteins | INCYTE CORPORATION (US) | 2025-02-18 | — | — | US | disclosed |
| US-20240002381-A1 | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | INCYTE CORPORATION | 2024-01-04 | — | — | US | disclosed |
| US-20230341777-A1 | RESIST UNDERLAYER FILM-FORMING COMPOSITION CONTAINING TERMINAL-BLOCKED REACTION PRODUCT | NISSAN CHEMICAL CORPORATION (JP) | 2023-10-26 | — | — | US | disclosed |
| US-20230341777-A1 | RESIST UNDERLAYER FILM-FORMING COMPOSITION CONTAINING TERMINAL-BLOCKED REACTION PRODUCT | NISSAN CHEMICAL CORPORATION (JP) | 2023-10-26 | — | — | US | disclosed |
| EP-0067793-B1 | PRESSURE OR HEAT SENSITIVE RECORDING MATERIALS | CIBA-GEIGY AG (CH) | 1985-04-17 | — | — | EP | disclosed |
| EP-0112291-A2 | Heat-sensitive registration material | CIBA-GEIGY AG (CH) | 1984-06-27 | — | — | EP | disclosed |
| US-4453744-A | Pressure-sensitive or heat-sensitive recording material | CIBA-GEIGY CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| EP-0070443-A1 | Thionophosphonic acid esters, process for preparing them and their use as pesticides | BAYER AG (DE) | 1983-01-26 | — | — | EP | disclosed |
| EP-0067793-A2 | Pressure or heat sensitive recording materials | CIBA-GEIGY AG (CH) | 1982-12-22 | — | — | EP | disclosed |
| US-4190652-A | Combating pests with O-phenyl-thionothiolalkanephosphonic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1980-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119365-A1 | NOVEL ACTIVATORS OF GLUCOKINASE | GCKR, GCK, HK1 | CA2 532/4885PSIP1 2133/4885ENPP2 2324/4885 |
| US-20240002381-A1 | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | BRD3, BRD1, BRD2 | CA2 4825/4885PSIP1 493/4885ENPP2 3937/4885 |
| US-20250145621-A1 | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | BRD3, BRD1, BRD2 | CA2 4825/4885PSIP1 493/4885ENPP2 3937/4885 |
| US-20110294758-A1 | NOVEL ACTIVATORS OF GLUCOKINASE | GCKR, GCK, HK1 | CA2 532/4885PSIP1 2133/4885ENPP2 2324/4885 |
| US-12227502-B2 | 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c] pyridin-7(6H)-ones as inhibitors of BET proteins | BRD3, BRD1, BRD2 | CA2 4825/4885PSIP1 493/4885ENPP2 3937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.