Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 6/20 | 0.42 |
| ▸ | NOS3 | P29474 | 4/20 | 0.42 |
| ▸ | NOS2 | P35228 | 4/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propanol SCHEMBL11577034 | 0.89 | NOS1 (0.35) | NOS1NOS3NOS2 | |
| SCHEMBL9559207 | 0.73 | NOS1 (0.47) | NOS1NOS3NOS2ADRA1A | |
| SCHEMBL145755 | 0.71 | NOS1 (0.50) | NOS1NOS3NOS2ADRA1A | |
| SCHEMBL30074503 | 0.71 | NOS1 (0.50) | NOS1NOS3NOS2ADRA1A | |
| SCHEMBL16115899 | 0.69 | NOS1 (0.44) | NOS1NOS3NOS2 | |
| SCHEMBL1012779 | 0.69 | NOS1 (0.40) | NOS1NOS3NOS2ADRA1A | |
| SCHEMBL3922142 | 0.69 | NOS1 (0.40) | NOS1NOS3NOS2ADRA1A | |
| SCHEMBL29357835 | 0.69 | NOS1 (0.40) | NOS1NOS3NOS2ADRA1A | |
| SCHEMBL27199706 | 0.67 | NOS1 (0.38) | NOS1NOS3NOS2 | |
| SCHEMBL1005903 | 0.67 | NOS1 (0.41) | NOS1NOS3NOS2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010531-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVE WITH ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2009-01-07 | — | — | EP | claimed |
| EP-1868600-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES FOR USE IN THE TREATMENT OF SUBSTANCE DEPENDENCY | Grünenthal GmbH (DE) | 2007-12-26 | — | — | EP | claimed |
| WO-2007124903-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVE WITH ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2007-11-08 | — | — | WO | claimed |
| WO-2006108565-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES FOR USE IN THE TREATMENT OF SUBSTANCE DEPENDENCY | Grünenthal GmbH (DE) | 2006-10-19 | — | — | WO | claimed |
| EP-3003279-A1 | TAMPER-RESISTANT DOSAGE FORM CONTAINING ONE OR MORE PARTICLES | Grünenthal GmbH (DE) | 2016-04-13 | — | — | EP | disclosed |
| EP-2928894-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF THE SODIUM IODIDE SYMPORTER | Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR) | 2015-10-14 | — | — | EP | disclosed |
| EP-2838512-A1 | TAMPER RESISTANT AND DOSE-DUMPING RESISTANT PHARMACEUTICAL DOSAGE FORM | Grünenthal GmbH (DE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2819656-A1 | TAMPER-RESISTANT DOSAGE FORM COMPRISING PHARMACOLOGICALLY ACTIVE COMPOUND AND ANIONIC POLYMER | Grünenthal GmbH (DE) | 2015-01-07 | — | — | EP | disclosed |
| WO-2014191397-A1 | TAMPER-RESISTANT DOSAGE FORM CONTAINING ONE OR MORE PARTICLES | Grünenthal GmbH (DE) | 2014-12-04 | — | — | WO | disclosed |
| CN-103965207-A | Preparation of novel tetrahydropyrano[3,4-b]indole derivatives and application of derivative in antitumor drugs | TIANJIN JINYU PHARMACEUTICAL TECHNOLOGY CO LTD | 2014-08-06 | — | — | CN | disclosed |
| CN-103965207-A | Preparation of novel tetrahydropyrano[3,4-b]indole derivatives and application of derivative in antitumor drugs | TIANJIN JINYU PHARMACEUTICAL TECHNOLOGY CO LTD | 2014-08-06 | — | — | CN | disclosed |
| WO-2014083529-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF THE SODIUM IODIDE SYMPORTER | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2014-06-05 | — | — | WO | disclosed |
| WO-2012028318-A1 | TAMPER RESISTANT DOSAGE FORM COMPRISING AN ANIONIC POLYMER | Grünenthal GmbH (DE) | 2012-03-08 | — | — | WO | disclosed |
| US-7820825-B2 | N-substituted-azacyclylamines as histamine-3 antagonists | WYETH LLC (US) | 2010-10-26 | — | — | US | disclosed |
| US-20100158905-A1 | COMBINATION THERAPY OF ARTHRITIS WITH TRANILAST | NUON THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| EP-2010531-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVE WITH ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2009-01-07 | — | — | EP | disclosed |
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007124903-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVE WITH ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2007-11-08 | — | — | WO | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |
| US-20070219240-A1 | N-substituted-azacyclylamines as histamine-3 antagonists | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100158905-A1 | COMBINATION THERAPY OF ARTHRITIS WITH TRANILAST | PTGS2, PTGES2, PTGES | NOS1 93/4885NOS3 82/4885NOS2 18/4885 |
| US-20070219240-A1 | N-substituted-azacyclylamines as histamine-3 antagonists | HNMT, HRH4, HRH3 | NOS1 2714/4885NOS3 1255/4885NOS2 2386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.