Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Nitrous Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrous Acid SCHEMBL27759988 | 1.00 | — | — | |
| Nitrous Acid SCHEMBL28294610 | 0.94 | — | — | |
| Nitrous Acid SCHEMBL42672 | 0.94 | — | — | |
| Nitrous Acid SCHEMBL557728 | 0.88 | ALDH1A1 (0.67) | — | |
| Nitrous Acid SCHEMBL23910148 | 0.88 | ALDH1A1 (0.67) | — | |
| Nitrous Acid SCHEMBL23456536 | 0.88 | ALDH1A1 (0.67) | — | |
| Nitrous Acid SCHEMBL25419792 | 0.88 | ALDH1A1 (0.67) | — | |
| Nitrous Acid SCHEMBL21830598 | 0.88 | ALDH1A1 (0.67) | — | |
| Nitrous Acid SCHEMBL22406196 | 0.88 | ALDH1A1 (0.67) | — | |
| Nitrous Acid SCHEMBL72504 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220273702-A1 | HYDROGEN SULFIDE AND NITRIC OXIDE THERAPY FOR COVID-19 INFECTION | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2022-09-01 | — | — | US | claimed |
| US-12139402-B2 | Pharmaceutical formulations of nitrite and uses thereof | BOARD OF SUPERVISORS OF LOUISIANSA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2024-11-12 | — | — | US | disclosed |
| US-20220273702-A1 | HYDROGEN SULFIDE AND NITRIC OXIDE THERAPY FOR COVID-19 INFECTION | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2022-09-01 | — | — | US | disclosed |
| US-20220169508-A1 | PHARMACEUTICAL FORMULATIONS OF NITRITE AND USES THEREOF | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2022-06-02 | — | — | US | disclosed |
| US-11247902-B2 | Pharmaceutical formulations of nitrite and uses thereof | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE | 2022-02-15 | — | — | US | disclosed |
| US-11116731-B2 | Hydrogen sulfide and/or nitrite in the treatment and prevention of atrial fibrillation | Brd. of Sup. of LSU and A &M College (US) | 2021-09-14 | — | — | US | disclosed |
| US-10864207-B2 | Method of treating endothelial dysfunction | Celagenex Research (India) Pvt. Ltd. (IN) | 2020-12-15 | — | — | US | disclosed |
| US-20200297756-A1 | PHARMACEUTICAL FORMULATIONS OF NITRITE AND USES THEREOF | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE | 2020-09-24 | — | — | US | disclosed |
| US-20200222383-A1 | POTENT SYNERGISTIC COMPOSITIONS OF VASOACTIVE MEDIATORS ENHANCERS FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION | Celagenex Research (India) Pvt. Ltd. (IN) | 2020-07-16 | — | — | US | disclosed |
| WO-2020141546-A1 | SYNERGISTIC NUTRITIONAL COMPOSITIONS FOR PAIN MANAGEMENT | Celagenex Research (India) Pvt. Ltd. (IN) | 2020-07-09 | — | — | WO | disclosed |
| US-20140127329-A1 | USE OF NITRITES FOR THE TREATMENT OF CEREBRAL AMYLOID ANGIOPATHY, AGE ASSOCIATED DEMENTIA, AND COGNITIVE DECLINE | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140112983-A1 | NITRITE COMPOSITIONS AND USES THEREOF | THERAVASC INC. (US) | 2014-04-24 | — | — | US | disclosed |
| US-20130209584-A1 | PHARMACEUTICAL FORMULATIONS OF NITRITE AND USES THEREOF | THERAVASC INC. (US) | 2013-08-15 | — | — | US | disclosed |
| WO-2012142413-A2 | NITRITE COMPOSITIONS AND USES THEREOF | THERAVASC INC. (US) | 2012-10-18 | — | — | WO | disclosed |
| WO-2012135623-A1 | USE OF NITRITES FOR THE TREATMENT OF CEREBRAL AMYLOID ANGIOPATHY, AGE ASSOCIATED DEMENTIA, AND COGNITIVE DECLINE | THERAVASC INC. (US) | 2012-10-04 | — | — | WO | disclosed |
| CN-102686111-A | Pharmaceutical formulations of nitrite and uses thereof | THERAVASC LLC | 2012-09-19 | — | — | CN | disclosed |
| EP-2488035-A1 | PHARMACEUTICAL FORMULATIONS OF NITRITE AND USES THEREOF | Theravasc Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011047161-A1 | PHARMACEUTICAL FORMULATIONS OF NITRITE AND USES THEREOF | TheraVasc, LLC (US) | 2011-04-21 | — | — | WO | disclosed |
| US-20110086069-A1 | PHARMACEUTICAL FORMULATIONS OF NITRITE AND USES THEREOF | TheraVasc, LLC (US) | 2011-04-14 | — | — | US | disclosed |
| US-4881977-A | RECORDING FLUIDS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1989-11-21 | — | — | US | disclosed |