Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 6/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10508264 | 0.87 | CSNK2A1 (0.51) | CSNK2A2CSNK2BCSNK2A1CYP1A2HSD17B10 | |
| SCHEMBL27034883 | 0.79 | CSNK2A2 (0.41) | CSNK2A2CSNK2BCSNK2A1CYP1A2HSD17B10 | |
| SCHEMBL15389101 | 0.78 | NR4A2 (0.46) | HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL12748348 | 0.77 | CSNK2A2 (0.60) | CSNK2A2CSNK2BCSNK2A1CYP1A2HSD17B10 | |
| SCHEMBL2075700 | 0.75 | CNR1 (0.39) | — | |
| SCHEMBL7827856 | 0.72 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGD | |
| SCHEMBL7012509 | 0.71 | CSNK2A1 (0.41) | CSNK2A2CSNK2BCSNK2A1CYP1A2HSD17B10 | |
| SCHEMBL16597426 | 0.69 | CYP1A2 (0.39) | CSNK2A2CSNK2BCSNK2A1CYP1A2HSD17B10 | |
| SCHEMBL1275907 | 0.69 | ADRA2A (0.50) | CSNK2A2CSNK2BCSNK2A1CYP1A2HSD17B10 | |
| SCHEMBL14037111 | 0.68 | CSNK2A1 (0.39) | CSNK2A2CSNK2BCSNK2A1CYP1A2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105593211-B | Indole and indazole derivatives | 豪夫迈·罗氏有限公司 | 2021-07-27 | — | — | CN | disclosed |
| EP-3049391-B1 | INDOLE AND INDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2018-12-26 | — | — | EP | disclosed |
| US-9708259-B2 | Indol and indazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-07-18 | — | — | US | disclosed |
| EP-3049391-A1 | INDOL AND INDAZOL DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-08-03 | — | — | EP | disclosed |
| US-20160207885-A1 | INDOL AND INDAZOL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-07-21 | — | — | US | disclosed |
| CN-105593211-A | Indol and indazol derivatives | HOFFMANN LA ROCHE | 2016-05-18 | — | — | CN | disclosed |
| WO-2015044072-A1 | INDOL AND INDAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207885-A1 | INDOL AND INDAZOL DERIVATIVES | CHRNA7, CHRM1, CHRNA3 | CSNK2A2 474/4885CSNK2B 463/4885CSNK2A1 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.